Drosophila PR-Set7 or SET8 is a histone methyltransferase that specifically monomethylates histone H4 lysine 20 (H4K20). L(3)MBT has been identified as a reader of methylated H4K20. It contains several conserved domains including three MBT repeats binding mono- and dimethylated H4K20 peptides. We find that the depletion of PR-Set7 blocks de novo H4K20me1 resulting in the immediate activation of...

BACKGROUND Congenital adrenal hyperplasia is a group of autosomal recessive disorders caused by a deficiency of 1 of 4 enzymes required for the synthesis of glucocorticoids, mineralocorticoids, and sex hormones. Analysis of 11-deoxycortisol (11DC), 17-hydroxyprogesterone (17OHP), 17-hydroxypregnenolone (17OHPr), and pregnenolone (Pr) in blood allows detection of these enzyme defects. METHODS ...

The mechanism of action of MD1, a new biotechnological radiotherapeutic agent of plant origin, on smooth muscle contraction was investigated. Contraction induced by MD1 consists of an initial dose-dependent transient phasic response (PR) (with ED50 = 0.11 +/- 0.02%, n = 4, the time of rise 15 s, onset of decay about 30 s) followed by a tonic contraction (TC) (at 10% MD1 only) with a maximum in ...

The absolute value of the Möbius function of a bounded poset P with n + 2 elements satisfies |μ(P )| ≤ max r≥0 max p1+...+pr=n pi≥1 r ∏

This article takes its name and inspiration from Mad Professor’s album A Caribbean Taste of Technology in response to the theme of this Technosphere issue. This makes a good place to start a discussion of creolization and technology – the dub reggae tracks of this album produced British producer Mad Professor and released in 1985, https://www.youtube.com/watch?v=ewDTHfJqLwI So what I present he...

Reaction of the complex [CpRe(NO)(CO)2]BF4 with triisopropylphosphine gives the chiral CO substitution product [CpRe(NO){P(/-Pr)3}(CO)]BF4. The corresponding triphenylphosphite complex [CpRe(NO){P(OPh)3}(CO)]BF4 may be obtained by oxidative CO removal. Reduction of the remaining CO ligand with NaBH4 furnishes the corresponding methyl com­ plexes [CpRe(NO)(L)(CH3)]. The structure of [CpRe(NO){P(...

Lan hài Đốm (Paphiopedilum concolor Lindl. Pfitz) là loài bản địa của miền Bắc Việt Nam. Hiện nay, này đã bị khai thác cạn kiệt ngoài tự nhiên nên việc phát triển phương pháp nhân giống in vitro để bảo tồn rất cần thiết. Bài báo trình bày kết quả nghiên cứu về một số yếu tố ảnh hưởng đến hiệu bao gồm môi trường khoáng phù hợp cho hạt nảy mầm, cây con từ hạt, tái sinh chồi và trưởng vitro. Kết t...

We discovered a 1,3-dipolar species co-existing in two different structures. Photolysis of matrix-isolated 5-phenyltetrazole generates two forms of phenylnitrile imine: propargylic and allenic. They are not resonance structures but correspond to different energy minima, representing bond-shift isomers. These distinct species were characterized spectroscopically and confirmed by calculations up ...

THIS APPENDIX PROVIDES a simple model of basis risk based on Clarke (2011) and uses it to argue that our 2011 insurance experiment can be used to test whether migration is risky and migrants are risk averse.1 There are two payoff-relevant states {L H} which lead to income at the destination yL ≤ yH . We assume pr(H) = πy . There are two rainfall states {RL RH} and rainfall insurance makes a pay...