objective: after the introduction of assisted reproductive techniques, human embryos were officially introduced into laboratories and now thousands of them are cryopreserved in such settings. embryonic stem cells and the future application of such cells in the treatment of disease opened the door to further research on human embryos. these developments raise many ethical issues, some of which h...

OBJECTIVES This qualitative study describes the experiences of spousal caregivers of a patient with end-stage heart failure (HF) from pre-LVAD to post-LVAD-DT implantation. BACKGROUND LVAD-DTs are implanted as permanent devices for end-stage HF patients with the goal of improving the length and quality of life. LVADs create new demands for both patients and caregivers. METHODS In-depth, sem...

I N the course of an investigation on the uptake of labelled ions by the rabbit embryo and its environment (Lutwak-Mann, Boursnell, & Bennett, 1960), experiments were done on pre-implantation blastocysts obtained from rabbits which had been treated parenterally with certain purine analogues. Histological examination of such blastocysts by the method of Moog & Lutwak-Mann (1958) showed that, as ...

Objective: Although cochlear implantation is widely applied, its outcomes are not very predictable on an individual basis. Several factors, such as the duration of deafness and the pre-operative speech understanding, have been identified as potential predictors. However, the relative value of these predictors varies between studies. This study evaluated the effect of the duration of post-operat...

AIMS This trial was designed to test the hypothesis that shock efficacy during follow-up is not impaired in patients implanted without defibrillation (DF) testing during first implantable cardioverter-defibrillator (ICD) implantation. METHODS AND RESULTS Between February 2011 and July 2013, 1077 patients were randomly assigned (1 : 1) to first time ICD implantation with (n = 540) or without (...

PURPOSE To evaluate the impact of pre-procedural coronary plaque composition assessed by virtual histology intravascular ultrasound (VH-IVUS) on late stent malapposition assessed by optical coherence tomography (OCT) following drug-eluting stent (DES) implantation. MATERIALS AND METHODS The study population consisted of 121 patients (121 lesions) who underwent both pre-procedural VH-IVUS and ...

Background:Cataract extraction surgery significantly decreases intraocular pressure (IOP) in patients with various forms of angle closure glaucoma (ACG). However, most reports did not specify the circumferential extent of peripheral anterior synechiae (PAS). Objective: Evaluate IOP after phacoemulsification with intraocular lens (IOL) implantation in chronic ACG patients without extensive PAS. ...

Background: HOXA11 and leukemia inhibitory factor (LIF) and basic transcriptional element binding protein1 (BTEB1) are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. In this case-control study, the expression pattern of these mRNA was evaluated in patients with endometriosis at the time of implantatio...

Summary Understanding lineage specification during human pre-implantation development is a gateway to improving assisted reproductive technologies and stem cell research. Here we employ pseudotime analysis of single-cell RNA sequencing (scRNA-seq) data reconstruct early mouse embryo development. Using time-lapse imaging annotated embryos, provide an integrated, ordered, continuous tran...

Many investigators are interested in finding the new cultural systems that can support the in vitro development of pre-implantation embryos better. Previous studies suggested that growth factors such as epidermal growth factor (EGF) are important in pre-implantation embryo development and implantation process. On the other hand, it is very important to support post thaw development of frozen em...