The system comprised of Kit Ligand (KL) and its receptor c-Kit has proven to play a role in normal female reproduction and fertility in mammals. Gene expression studies have revealed that biological activities of ligands and receptors of the KL/c-Kit system are important in controlling apoptosis and cellular proliferation in reproductive tissues. Collectively, these studies have provided a bett...

Females are born with a finite number of primordial follicles. 4-Vinylcyclohexene diepoxide (VCD) is a metabolite formed by epoxidation of 4-vinylcyclohexene (VCH) via its two monoepoxides 1,2- and 7,8-4-vinylcyclohexene monoepoxide (VCM). VCD specifically destroys small preantral (primordial and small primary) follicles in the rodent ovary. The phase I enzyme, cytochrome P450 isoform 2E1 (CYP2...

Background: Nanoparticles (NPs) are small-sized particles with dimensions of 1 - 100 nm that have various medical and pharmaceutical technology applications. Objectives: In this study, we aimed to develop a quick, green, eco-friendly procedure for the synthesis gold NPs (AMGNPs) using aqueous extract Achillea millefolium (AM) evaluate effects them on preantral follicle (PF) maturation in vitro ...

BACKGROUND With infertility populations in the developed world rapidly aging, treatment of diminished ovarian reserve (DOR) assumes increasing clinical importance. Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances with DOR, and is now utilized by approximately one third of all IVF centers world-wide. Increasing DHEA utilization and publication of a first prospectively...

Polycystic Ovary Syndrome (PCOS) is a common endocrine-reproductive disease in females. PCOS patients show decreased ovary granular cells, which is possibly related with cell apoptosis. This study thus aimed to investigate the apoptotic mechanism in PCOS via measuring the protein expressions of apoptosis and anti-apoptosis related molecules in PCOS patients. A total of 30 PCOS patients were rec...

Background: With all the recent advances in cancer treatments, many young cancer patients find themselves facing the prospect of losing their fertility after aggressive chemotherapy or radiotherapy. Cryopreservation of ovarian cortical tissue has emerged as a potential option to restore fertility in these young women. Materials and Methods: Because autotransplantation of cryopreserved ovarian c...

Previous studies have reported many discrepancies about the best type and concentration of cryoprotective agents (CPAs) and biological variability among various pre-antral follicle classes after cryopreservation of ovarian tissue. The aim of this study was to investigate the impacts of some synthetic polymers on histological characteristics of different types of pre-antral follicles after bovin...