The Polycomb group proteins are transcriptional repressors that are thought to act through multimeric nuclear complexes. We show that ph and Psc coprecipitate with Pc from nuclear extracts. We have analyzed the domains required for the association of Psc with ph and Pc by using the yeast two-hybrid system and an in vitro protein-binding assay. Psc and ph interact through regions of sequence con...

Edina Nagy-Baló, Diana Tint, Marcell Clemens, Ildikó Beke, Katalin Réka Kovács, László Isolation: A Comparison of Two Ablation Techniques Transcranial Measurement of Cerebral Microembolic Signals During Pulmonary Vein Print ISSN: 1941-3149. Online ISSN: 1941-3084 Copyright © 2013 American Heart Association, Inc. All rights reserved. Avenue, Dallas, TX 75231 is published by the American Heart As...

Here, we demonstrated that DNA-PKcs is over-expressed in multiple human renal cell carcinoma (RCC) tissues and in primary/established human RCCs. Pharmacological or genetic inhibition of DNA-PKcs suppressed proliferation of RCC cells. DNA-PKcs was in the complex of mTOR and SIN1, mediating mTORC2 activation and HIF-2α expression in RCC cells. Inhibiting or silencing DNA-PKcs suppressed AKT Ser-...

Measurements of thermal conductivity and thermal diffusivity have been made on two samples of Climax Stock quartz monzonite at pressures between 3 and 50 MPa and temperatures between 300 and 523 K. Following those measurements, the apparatus was calibrated with respect to the thermal conductivity measurement using a reference standard of fused silica. Corrected thermal conductivity of the rock ...

Based on a high-quality dataset of 713 daily precipitation series, changes in daily precipitation events during 1960–2013 were observed in China’s ten largest river basins. Specifically, the amount of precipitation in four categories defined by fixed thresholds and their proportion on total precipitation were analyzed on annual and seasonal time scales. Results showed annual precipitation incre...

Although precipitation interannual variability is projected to increase due to climate change, effects of changes in precipitation variance have received considerable less attention than effects of changes in the mean state of climate. Interannual precipitation variability effects on functional diversity and its consequences for ecosystem functioning are assessed here using a 6-year rainfall ma...

Molecular dynamics simulations of Cm(III) in water were performed at two different temperatures, namely, T = 300 K and T = 473 K. Fully ab initio intermolecular potentials were employed. At the lower temperature, T = 300 K, nine water molecules coordinate preferentially the Cm(III) ion in the first coordination sphere, while at the higher temperature, T = 473 K, the preferential coordination nu...