نتایج جستجو برای: precision 122
تعداد نتایج: 128255 فیلتر نتایج به سال:
the purpose of this study is to identify the barriers of application of precision farming in the view of agricultural researchers in khouzestan province. the research method was survey. agricultural researchers in khouzestan province considered as statistical population (n=136). all researchers considered as sample size by census method. after designing and validating the questionnaire, the qu...
چکیده: عفونت با هپاتیت c یکی از مهمترین عوامل بیماریهای کبدی است و بیش از 170 میلیون نفر در سراسر دنیا به این ویروس آلوده اند. بعد از مراحل تحت بالینی بیماری بیش از 80 درصد افراد مبتلا به هپاتیت c به عفونت دائم هپاتیت مبتلا می شوند که همراه با بیماریهای مزمن کبدی است که پیامد آن سیروز و سرطان کبد است. مطالعات سعی نموده اند تا یک مارکر اختصاصی تر و قابل اطمینان تر در جهت کامل نمودن میزان alt و ...
OBJECTIVE Intratumoral administration of adenoviral vector encoding herpes simplex virus (HSV) thymidine kinase (TK) gene (Ad-TK) followed by systemic ganciclovir (GCV) is an effective approach in treating experimental hepatocellular carcinoma (HCC). However, hepatotoxicity due to unwanted vector spread and suicide gene expression limited the application of this therapy. miR-122 is an abundant,...
These studies show that miR-122, a 22-nucleotide microRNA, is derived from a liver-specific noncoding polyadenylated RNA transcribed from the gene hcr. The exact sequence of miR-122 as well as the adjacent secondary structure within the hcr mRNA are conserved from mammalian species back to fish. Levels of miR-122 in the mouse liver increase to half maximal values around day 17 of embryogenesis,...
Hepatic miR-122 can serve as a pro-apoptotic factor to suppress tumorigenesis. The underlying mechanism, however, remains incompletely understood. Here we present the first evidence that miR-122 promotes hepatocellular carcinoma cell apoptosis through directly silencing the biogenesis of cell survival oncomiR miR-21 at posttranscriptional level. We find that miR-122 is strongly expressed in pri...
Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a powerful technique for their functionalization. To uncover the role of the liver-specific miR-122 in the adult liver, we inhibited it in mice with a 2'-O-methoxyethyl phosphorothioate ASO. miR-122 inhibition in normal mice resulted in reduced plasma cholesterol levels, inc...
Doxorubicin (DOX) is one of the most commonly used anticancer drugs in the treatment of hepatoma. However, acquired drug resistance is one of the major challenges for the chemotherapy. In this study, a down-regulation of miR-122 was observed in doxorubicin-resistant Huh7 (Huh7/R) cells compared with its parental Huh7 cells, suggesting miR-122 is associated with the chemoresistance. Meanwhile, l...
The exploration of superconducting iron-free pnictides with a ThCr2Si2-type or related structure and the study of their superconducting properties are important in order to get a deeper understanding of the pairing mechanism of 122 iron pnictides. Here we review the properties of 122-type iron-free pnictides superconductors with structures similar to that of BaFe2As2. Evidence of fully gapped n...
Tristan McGeorge, Jamie Hacker Hughes and Simon Wessely consider a High Court judgment on liability for post-traumatic stress disorder in the military. In 2003, the High Court of England and Wales handed down judgment in what has come to be known as the Ministry of Defence (MoD) post-traumatic stress disorder (PTSD) case1. This was a class action brought by more than 2,000 British military pers...
در این پروژه ما قابلیت روش آنالیز مستقیم جیوه (dma) را برای به کار گیری در تعیین مقدار جیوه در واکسن ها را مورد بررسی قرار دادیم. این روش یک روش کاملا اختصاصی است و ترکیبات موجود در ماتریکس واکسن که مهمترین آنها آلومینیوم می باشد در این واکنش تداخلی در جهت افزایش کاذب و یاکاهش کاذب مقدار جیوه ایجاد نمی کنند. به دلیل این اختصاصی بودن (specificity) نتایج حاصل از آن کاملا قابل اعتماد و صحیح (accur...
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