Generalized anxiety disorder (GAD) is a common disorder that is chronic, disabling, and often goes undiagnosed. Currently, four distinct classes of medications have demonstrated efficacy in the treatment of GAD: benzodiazepines, serotonin and/or norepinephrine reuptake inhibitors (SSRIs/SNRIs), histamine H1 receptor blockers (hydroxyzine), and pregabalin. Pregabalin acts via binding to an α2-δ ...

OBJECTIVES To evaluate the effects of adjunctive pregabalin 300 mg/day versus placebo on polysomnographic (PSG) variables in patients with well controlled partial seizures and subjectively reported sleep disturbance. METHODS An exploratory, 4-week, double-blind, randomized study in patients with well controlled partial seizures on AED monotherapy and subjective sleep disturbance over the prev...

UNLABELLED Fibromyalgia is a difficult-to-treat chronic pain syndrome that affects 2% of the US population. Pregabalin is an antiepileptic recently FDA approved for fibromyalgia treatment. Other antiepileptics have been suggested for treatment. This systematic review examines the relative benefits and harms of antiepileptic drugs in the treatment of fibromyalgia. A literature search was conduct...

background: laparascopic surgery is associated with post operative pain .optimal pain treatment with minimal side effects is essential for early recovery and mobility in patients undergoing laparoscopic surgery .we compaired the analgesic effect pregabalin and gabapentin with different doses in this surgical procedurs.methods: in a randomized , double blind , ninety patients were  allocated to ...

INTRODUCTION Fibromyalgia is a chronic disorder characterized by widespread pain and tenderness. Prior trials have demonstrated the efficacy of pregabalin for the relief of fibromyalgia symptoms, and it is approved for the treatment of fibromyalgia in the United States. However, prior to this study, there has not been a large-scale efficacy trial in patients with fibromyalgia in Japan. METHOD...

This study involves the efficacy of pregabalin combined with celecoxib for acute pain treatment in patients lumbar disc herniation. Selected 142 due to herniation undertreated our hospital from May 2019 March 2021 and randomly divided them into a control group group. Control (n=71) accepted conventional celecoxib, after same as group, they received another pregabalin, both groups were treated c...

Pooled data analysis was performed on individual data from 807 pregabalin- and 367 placebo-treated patients with treatment-resistant partial seizures with or without generalization from four placebo-controlled studies evaluating the short-term efficacy, safety and tolerability of add-on pregabalin 150-600 mg/day. Short-term add-on treatment with pregabalin resulted in statistically significant ...

To analyze the effect of loss of exclusivity of data on the cost of treatment of peripheral neuropathic pain (PNP) with pregabalin or gabapentin in routine clinical practice. A retrospective observational study, with electronic medical records for patients enrolled at primary care centers managed by the health care provider Badalona Serveis Assistencials, who initiated treatment of PNP with pre...

UNLABELLED The purpose of our study was the experimental research on the effects of pregabalin in two behavioural models in mice. MATERIAL AND METHODS The experiment was carried out with white Swiss mice treated intraperitoneally as follows: Group I (Control): distilled water 0.1 ml/10 g body weight; Group II (PGB 10): 10 mg/kbw pregabalin; Group III (PGB 20): 20 mg/kbw pregabalin. The psycho...

BACKGROUND In this prospective, randomized, double-blind, placebo-controlled study, we investigated the effect of pregabalin on oxycodone consumption, postoperative confusion, and pain in elderly cardiac surgery patients. METHODS Seventy patients, aged ≥75 yr, were randomized to receive either 150 mg of pregabalin before operation and 75 mg of pregabalin twice daily for 5 postoperative days o...