OBJECTIVE Ovarian fibrosis is characterized by excessive proliferation of ovarian fibroblasts and deposition of extracellular matrix (ECM) and it is one of the principal reasons for ovarian dysfunction. This review aimed to investigate the pathogenetic mechanism of ovarian fibrosis and to clarify the relationship between ovarian diseases and fibrosis. DATA SOURCES We searched PubMed for Engli...

The premature ovarian failures with underlying chromosomal abnormalities are normally X-linked, although their associations with the autosomal and the Robertsonian translocations are also possible. Here, we are reporting a case of premature ovarian failure which was associated with a translocation between the long arm of chromosome 7 at q11.23 and the short arm of chromosome 5 at p15.3. The pro...

The aim of this study was to trigger the expression of genes related to oocytes in putative ovarian stem cells scraped from the ovarian surface epithelium of women with premature ovarian failure and cultured in vitro in the presence of follicular fluid, rich in substances for oocyte growth and maturation. Ovarian surface epithelium was scraped and cell cultures were set up by scrapings in five ...

Management considerations Pretreatment evaluation Vasomotor symptoms Urogenital and Vaginal symptoms The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women Progestogen indication Venous thromboembolism Stroke Diabetes mellitus Breast cancer Endometrial cancer Ovarian cancer Colorectal cancer Gallbladder disease Osteoporosis Dementia and cognitive decline Dep...

Abstract Background Premature ovarian failure (POF)/premature insufficiency (POI) is characterized by disrupting function under 40 years old. A major health problem of this disorder female infertility. There are no proven treatments to increase the rate pregnancy with autologous oocytes in these patients. This review aims summarize our present knowledge about POI-induced infertility and highlig...

In female, energy metabolism influences reproductive function by modulating the Hypothalamic Pituitary Ovarian axis including hypothalamic GnRH neuronal network, pituitary gonadotropin secretion and ovarian follicle growth steroidogenesis. Several hormones neuropeptides or metabolites are important signals between balance reproduction. These sensors mediate their action on cells through specifi...

we present 2 cases of likely rare event. in case 1, 3rd degree consanguineous marriage revealed inv(6) with same break points in parents who were found to be phenotypically normal. the same inv(6) being inherited in progeny but presented with low amh (anti mullerian hormone) and high level of fsh (follicular stimulating hormone) leading to polycystic ovarian syndrome/premature ovarian failure. ...

Objective: To evaluate whether systemic inflammatory markers (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and red blood cell distribution width (RDW) to platelet ratio (RPR)) can be used as reliable markers for the diagnosis of premature ovarian insufficiency (POI) and to determine if there is a relationship between these markers and follicle stimulating hormone (FS...