ObjectiveTo characterize circulating insulin-like factor 3 (INSL3) in different stages of ovarian insufficiency and its role the evaluation premature (POI).DesignRetrospective cohort study.SettingUniversity-based center for reproductive medicine.Patient(s)A total 145 women, including 48 patients with POI (25 IU/L < follicle-stimulating hormone [FSH] ?40 IU/L), 49 biochemical (bPOI) (10 FSH ?25 ...

Fragile X-associated primary ovarian insufficiency (FXPOI) is due to an X-linked mutation that results from the expansion of a CGG repeat sequence located in the 5' untranslated region of the FMR1 gene (premutation, PM). About 20% of women who carry the PM have cessation of menses before age 40, a clinical condition known as premature ovarian failure (POF). This leads to a 20-fold increased ris...

The combination of Müllerian agenesis with inguinal ovaries accompanied by primary ovarian insufficiency is extremely rare. A 21-year-old Korean woman was referred to our center with primary amenorrhea. The patient was diagnosed with Müllerian agenesis with inguinal ovaries. Her hormonal profile showed hypergonadotrophic hypogonadism suggesting primary ovarian insufficiency. We performed laparo...