نتایج جستجو برای: preopen sets
تعداد نتایج: 211027 فیلتر نتایج به سال:
Ranolazine is an approved drug for chronic stable angina that acts by suppressing a noninactivating current conducted by the cardiac sodium channel [persistent sodium ion current (INa)]. Ranolazine has also been shown to inhibit the increased persistent INa carried by NaV1.1 channels encoding epilepsy- and migraine-associated mutations. Here, we investigate the antiepileptic properties of ranol...
Kv2.1 channels exhibit a U-shaped voltage-dependence of inactivation that is thought to represent preferential inactivation from preopen closed states. However, the molecular mechanisms underlying so-called U-type inactivation are unknown. We have performed a cysteine scan of the S3-S4 and S5-P-loop linkers and found sites that are important for U-type inactivation. In the S5-P-loop linker, U-t...
In time–frequency analysis, an increasing interest is to develop various tools split a signal into set of non-overlapping frequency regions without the influence their adjacent regions. Although framelet ideal tool for most framelets only give overlapping partition domain. order obtain domain, sets and associated scaling are introduced. this study, we will investigate relation between (or scali...
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