1-substituted 1H-tetrazoles were efficiently synthesized under solvent-free conditions from the reaction of primary amines, triethylorthoformate, and sodium azide in the presence of Cu/C as a heterogeneous catalyst. Various amines including aromatic and heteroaromatic amines were used to afford the corresponding products in good to excellent yields. The characterization of corresponding product...

The preparation of heterobenzylic amines by a Ni-catalyzed reductive cross-coupling between heteroaryl imines and C(sp3) electrophiles is reported. This umpolung-type alkylation proceeds under mild conditions, avoids the pre-generation organometallic reagents, exhibits good functional group tolerance. Mechanistic studies are consistent with imine substrate acting as redox-active ligand upon coo...

An efficient dynamic kinetic resolution (DKR) approach for the synthesis of axially chiral diamines has been developed on basis a ruthenium-catalyzed enantioselective transfer hydrogenation. The strategy relies configurational instability cyclic biaryl aminal precursors in equilibrium with their amino-imine open forms, as supported by DFT calculations. This protocol features broad substrate sco...

A new optical sensing microplate was developed for rapid screening for the presence of biogenic amines (BAs) in seafood samples with high sensitivity. The deposition of a sensing spot (containing a chameleon dye (Py-1) in a polymeric cocktail) on the bottom of the wells of a standard microplate renders the plate a new sensing tool for a rapid and parallel detection of up to 96 (real) samples. T...

Supercritical carbon dioxide can be employed as an environmentally friendly alternative to conventional organic solvents for the synthesis of a variety of carboxylic amides. The addition of amines to ketenes generated in situ via the retro-ene reaction of alkynyl ethers provides amides in good yield, in many cases with ethylene or isobutylene as the only byproducts of the reaction. Reactions wi...

The integrated one-pot synthesis of valuable allylamines and alkylamines from amines, formaldehyde, terminal alkynes is achieved using a single catalyst material. This multifunctional catalytic system composed silica support on which are jointly assembled ruthenium nanoparticles covalently functionalized copper N-heterocyclic carbene (NHC) complexes, introducing new generation immobilized molec...

KLOCKE, FRANCIS J., GERARD A. KAISER, JOHN Ross, JR., AND EUGENE BRAUNWALD. Mechanism of increase of myocardial oxygen uptake produced by catecholamines. Am. J. Physiol. 209(5) 913-918. 1965. -The relative roles of augmented hemodynamic performance and direct stimulation of oxidative metabolism in mediating the increase of myocardial oxygen uptake (MVo2) produced by catecholamines have been exa...

A series of block copolymers bearing a single amino in-chain functionality was synthesized via anionic polymerization of styrene and ethylene oxide. By means of both a conventional and a continuous setup, living polystyrene was quantitatively end functionalized with an oxirane (DBAG) prior to the polymerization of the poly(ethylene oxide) segment. The in-chain amine was conjugated with a fluore...

Using a-tetralone, as starting material, a series of phencyclidine analogues were synthesized. This ketone was reacted separately with ethylmagnesium bromide, P-methoxyphenylmagnesium bromide and P-methylphenylmagnesium bromide. The resultant alcohols were treated with a suspension of NaN3 and CCl3COOH in CHCl3. The azides were subsequently...

For the purpose of preparing liquefied graphene oxide (GO), a process consisting of sulfonation with sodium sulfanilic acid and ionization with bulky amine-terminated Jeffamine® was designed and performed. The obtained hybrid fluid is actually a supramolecular ionic liquid (SIL) with sulfonated GO as the central anions and the terminal ammonium groups of Jeffamine® as the surrounding cations. T...