As the dawn of this new decade has begun, we have faced our arch-nemesis right at the start in the form of Coronavirus also known as COVID-19. Since its origin from Wuhan, China, it has been declared a pandemic and has effected several countries worldwide. This review article summarizes all the research, techniques, strategies, and treatment methodologies that are taking place internationally i...

I MAKE no apology for speaking to you tonight in my presidential address on diabetes. During more than thirty years I have done much work at this disease, having seen more than ten thousand cases of it in all, and having been concerned in its investigation and treatment both in the pre-insulin and insulin eras. At the beginning of my medical life very little in the way of practical useful treat...

Neglected Diseases R ecent experience with SARS (severe acute respiratory syndrome) [1] and avian flu shows that the public and political response to threats from new anthropozoonoses can be near-hysteria. This can readily make us forget more classical animal-borne diseases, such as plague (Box 1). Three recent international meetings on plague (Box 2) concluded that: (1) it should be re-emphasi...

Multiple myeloma is a clonal B-cell tumor of slowly proliferating plasma cells within the bone marrow. Among hematologic malignancies, it constitutes 10% of the cancers and ranks as the second most frequently occurring hematologic cancer in the United States, after non-Hodgkin lymphoma. Interleukin-6 is an important cytokine in myeloma cell growth and proliferation. Close cell-to-cell contact b...

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Liverpool’s designation as European Capital of Culture for 2008, together with the 800th anniversary of the founding of the borough in 2007, has (unsurprisingly) generated a number of books dealing with different aspects of the city’s history. The five volumes reviewed here represent just a small selection of those available, ranging from the deliberately academic to much more popular publicati...

Integrons are versatile gene acquisition systems commonly found in bacterial genomes. They are ancient elements that are a hot spot for genomic complexity, generating phenotypic diversity and shaping adaptive responses. In recent times, they have had a major role in the acquisition, expression, and dissemination of antibiotic resistance genes. Assessing the ongoing threats posed by integrons re...