Hyphomicrobium strain WC, Pseudomonas strain TP-1, and Pseudomonas strain W1 are capable of growth on methanol as the sole source of carbon and energy. Methanol-grown cells of each organism contain a primary alcohol dehydrogenase that has been purified to homogeneity. Each enzyme has a molecular weight of 120,000 and shows an in vitro requirement for phenazine methosulfate and ammonium ions for...

Modifiable factors have increasingly been associated with breast cancer. Studies have long suggested a link between modifiable factors, such as weight, physical activity, and alcohol use, and the risk of developing a primary breast cancer. Dozens of case-control and prospective cohort studies have demonstrated up to a two-fold increase in risk of breast cancer in overweight and obese postmenopa...

Approximately half of all people with high alcohol consumption in Sweden fulfill criteria for either harmful consumption or dependence. Among the alcohol-dependent, the majority have dependence with low severity. They are also reluctant to seek treatment. This qualitative study, with data from seven focus group discussions and 14 individual interviews, aims to describe and explain how represent...

AIM To estimate sex differences in health-care utilization among harmful/hazardous drinkers in the period before alcoholic cirrhosis diagnosis, and estimate sex differences in the extent to which alcohol use and brief alcohol interventions were documented for these individuals compared with a control cohort. DESIGN Retrospective study using linked general practice and hospital admissions data...

One of the goals of all pharmacological interventions aimed to increase the survival rateof patients with alcohol-dependent oropharyngeal cancers is to decrease alcohol use. Oxytocinis an alternative therapy for craving and alcohol management. However, the effectiveness ofoxytocin on the severity of alcohol dependence has not been evaluated. In an ABAB...

Research on associations between substances of abuse and suicidal behaviors is a large, complex area. Herein, alcohol, the most commonly abused intoxicant worldwide, is examined with a focus on two topics: (1) acute use of alcohol (AUA) shortly prior to suicidal behavior; and (2) more chronic alcohol use disorder (AUD) and suicidal behavior. First, a brief summary of what is known about AUA, AU...

The Alcohol Use Disorders Identification Test (AUDIT) has been developed from a six-country WHO collaborative project as a screening instrument for hazardous and harmful alcohol consumption. It is a 10-item questionnaire which covers the domains of alcohol consumption, drinking behaviour, and alcohol-related problems. Questions were selected from a 150-item assessment schedule (which was admini...

AIM To determine the effectiveness of medical counseling for alcohol abuse, when it is provided in primary care centers. DESIGN Quasi-experimental, open, multicenter before-after study.Setting. 14 primary care physician's practices (7 rural, 7 urban) in the province of Córdoba (Spain). PARTICIPANTS 306 patients of both sexes, recruited with a case-finding strategy, who consumed >=35 (men) o...

Purpose: Many studies on preoperative antiseptic agents are inconclusive. This study attempts to find the more effective combination agent in pediatric surgical patients.
 Methodology: was a prospective randomized paediatric patients. Preoperative skin preparation for each group done with assigned combination. Patients were followed up 14th,21st and 30th postoperative days. The primary out...