Background: There have been some reports about the possible N-methyl-D-aspartate (NMDA) antagonist activity of Guaifenesin. As drugs with a similar structure to Guaifenesin (i.e. Felbamate) and those with NMDA antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether Guaifenesin has an anticonvulsant effect in an animal model of seizure. ...

Carbamazepine in the treatment of generalised tonic clonic seizures in juvenile myoclonic epilepsy Juvenile myoclonic epilepsy is characterised by bilateral myoclonic jerks on wakening, and generalised tonic clonic seizures with onset in the mid-teens, which may be preceded by typical absences in 33% of patients.' Findings on EEG include bilateral spikes or multiple spike-slow wave discharges a...

A 65-year-old Japanese man with advanced chronic kidney disease (CKD) developed acute-onset type 1 diabetes mellitus (T1D) that was associated with severe acute kidney injury and was manifested by generalized tonic-clonic status epilepticus. His seizures resolved without recurrence after correcting the diabetic ketoacidosis. Although hyperglycemia is an important cause of acute symptomatic seiz...

Patients are not able to call for help during a generalized tonic-clonic epileptic seizure. Our objective was to develop a robust generic algorithm for automatic detection of tonic-clonic seizures, based on surface electromyography (sEMG) signals suitable for a portable device. Twenty-two seizures were analysed from 11 consecutive patients. Our method is based on a high-pass filtering with a cu...

Eyelid myoclonia with absences (EMA) and juvenile myoclonic epilepsy (JME) are two separate epileptic syndromes included in the new classification of epilepsies and epileptic syndromes by ILAE in 2001. Both are idiopathic generalized epilepsies with their clinical onset in the first two decades. EMA is characterized by eyelid myoclonia associated with absences and photosensitivity. Self-induced...

Dear Editor, We report a case of pulmonary edema following tonic–clonic seizure not associated with congestive heart failure. A 68-year-old man was transferred to our department with self-limited tonic–clonic seizure continuing for 3 min. The patient’s medical history was notable for epilepsy treated with carbamazepine (400 mg/day). The last seizure had occurred more than 25 years previously. T...

background: there have been some reports about the possible n-methyl-d-aspartate (nmda) antagonist activity of guaifenesin. as drugs with a similar structure to guaifenesin (i.e. felbamate) and those with nmda antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether guaifenesin has an anticonvulsant effect in an animal model of seizure. me...

Objective: Antiepileptic drugs (AEDs) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have seizures with current AEDs therapy. Some herbs which traditionally used in the management of seizures of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. The aim of the p...

The patient was a 41 year old woman that was brought to the emergency department (ED) by her husband following seizure. According to the relatives accompanying her, the seizure was of tonic-clonic type, had occurred one hour before presentation to ED, and had lasted 3 minutes. The patient had been drowsy for about 15 minutes after the end of the seizure. She had no history of head trauma and di...

A sample of 78 patients (32 females and 46 males) who had a first unprovoked generalized tonic-clonic seizure between the age of 3 and 21 years was studied prospectively. Duration of follow-up was 2-10 years (mean 5.2 years). A second seizure occurred in 69.2% (54 of 78), most commonly (38 of 54, 70.37%) in the first three months after the first seizure. There were no significant differences in...