Premature ovarian failure is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles/arrested folliculogenesis before the age of 40 years (secondary amenorrhea). Hormonally, POF is defined by abnormally low levels of estrogen and high levels of FSH, which demonstrate that the ovaries are no longer responding to circul...

Premature ovarian failure is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles/arrested folliculogenesis before the age of 40 years (secondary amenorrhea). Hormonally, POF is defined by abnormally low levels of estrogen and high levels of FSH, which demonstrate that the ovaries are no longer responding to circul...

Perrault syndrome 5 is a rare autosomal recessive disorder that characterized by the association of sensorineural hearing loss and ovarian dysgenesis in females with diversity neurologic deficits due to variants twinkle mtDNA helicase (<i>TWNK</i>) gene. Since develop gradually, patient often misdiagnosed other neurological disease during early age. Herein, we report case geneticall...

Premature ovarian failure is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles/arrested folliculogenesis before the age of 40 years (secondary amenorrhea). Hormonally, POF is defined by abnormally low levels of estrogen and high levels of FSH, which demonstrate that the ovaries are no longer responding to circul...

A primary ovarian pregnancy was diagnosed in a patient with intrauterine device. Primary ovarian pregnancy which is a rare form of ectopic pregnancy, was reviewed according to etiology, pathogenesis and improvements in diagnosis and therapy. In this article, our case was multiparous and used intrauterine device for 5 years. Ovarian pregnancy was diagnosed before operation. This diagnosis was ve...

Subject: Polycystic ovary syndrome (PCOS) is female disorder caused by cysts formation in ovarian that results of hormones secretion and menstrual cycle. Neuregulin 4 (NRG4) one adipokines family members synthesis release via adipose tissues, it acts as activator the epidermal growth factor receptor (EGFR).Objective Study: Assessment role NRG4 PCOS patients.Materials Methods: Present study incl...