Methods: Data from a total of 96 subjects, who received various dosages of oral and i.v. oseltamivir either in singleor repeated-dose regimens in four separate studies, and for whom rich PK data was available, were used for the development of the oseltamivir population PK model. Single dose data from 19 subjects in a fifth study, which included an OP arm and an OP + probenecid arm, were used to...

A simple, selective, rapid, precise and economical reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of nebivolol and hydrochlorthiazide from pharmaceutical formulation. Phenomenex Gemini C(18) (25 cm×4.6 mm i.d., 5 μ) column with a mobile phase consisting of acetonitrile: 50mM ammonium acetate (adjusted to pH 3.5 using orthophosphoric ...

The effect of ammonium chloride (systemic acidosis) and probenecid on the distribution of DMO in intraocular and cerebrospinal fluids has been studied. These drugs increased the level of DMO in intraocular fluids so that DMO was found in excess of plasma levels at plasma levels which normally result in a deficit of DMO in intraocular fluids. Their action seemed to be explained in part by a bloc...

A total of 136 patients with uncomplicated gonorrhoea were treated with intramuscular cefoxitin 2 g (25 patients) or 1 g (111 patients) and oral probenecid 1 g. Cefoxitin 1 g cured 95% (42 out of 45 men and all of 14 women) with infections caused by penicillinase producing Neisseria gonorrhoeae (PPNG) strains and 98% (all of 38 men and 13 out of 14 women) with non-PPNG infections, giving an ove...

In the early seventies we reported the occurrence of diminished post-probenecid accumulation of 5hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) in depression (van Praag el al. 1970; van Praag & Korf, 1971). Lowered baseline and post-probenecid 5-HIAA levels in CSF are an indication of diminished metabolism of the mother amine serotonin (5-hydroxytryptamine, 5HT) in the CNS. Low ...

The effects of OATP1B1, OAT3, and MRP2 on the pharmacokinetics of eluxadoline, an oral, locally active, opioid receptor agonist/antagonist being developed for treatment of IBS-d were assessed in vivo. Coadministration of a single 200 mg dose of eluxadoline with cyclosporine, and probenecid increased eluxadoline systemic exposure [AUC(0-inf) ] by 4.4- and 1.4-fold, respectively, whereas peak exp...

In the early seventies we reported the occurrence of diminished post-probenecid accumulation of 5hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) in depression (van Praag el al. 1970; van Praag & Korf, 1971). Lowered baseline and post-probenecid 5-HIAA levels in CSF are an indication of diminished metabolism of the mother amine serotonin (5-hydroxytryptamine, 5HT) in the CNS. Low ...

In this review the drugs capable of increasing or lowering the serum urate concentration are considered with regard to mechanism of action and significance of the effect, where known. Several hypouricemic agents, probenecid, sulfinpyrazone, and allopurinol, are considered in further detail because of their major clinical importance. No effort has been made, however, to summarize the relative ...