the forced degradation study of lidocaine hcl was carried out according to the ich guideline q1a (r2). the degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by gc-fid method and nuclear magnetic resonance (nmr) spectroscopy. according to these results, the degradation products were not obse...

1. In Expt I, a pelleted grass-meal diet was supplemented with hydrochloric acid, added to the grass pellets before feeding, at five levels from 0 to 628 mmol/kg dry matter (DM). Each diet was offered ad lib. for 21 d to five sheep in a 5 x 5 Latin-square design. 2. Voluntary food intake decreased rectilinearly with increasing HCl supplementation (P less than 0.001), to 42% of the control value...

Glaucoma is defined as the increase in the intraocular pressure (IOP) causing visual loss due to the circulation deficits of the aqueous humor. The IOP measurement can be obtained without any problem in calm animals. However, some animals do not allow IOP measurement without sedation or anesthesia. The purpose of this study is to determine the effect of xylazine HCl (as a sedative) and ketamine...

Drug-induced lupus is not a very common entity. Drugs like hydralazine, procainamide have been reported to induce lupus, but so far there is no case report of amiodarone-induced lupus in Indian literature. A case of atrial fibrillation in an elderly man who came with systemic features of lupus after amiodarone therapy for one and half years is reported.

Twenty patients with recurrent sustained ventricular tachycardia (VT) underwent serial electrophysiological studies (EPS) 1) to determine the predictive value of the EPS in the selection of antiarrhythmic therapy, and 2) to establish the therapeutic efficacy of available antiarrhythmic agents. In each patient VT could be reproducibly initiated by programmed stimulation. After control EPS, the e...

PURPOSE The purpose of this study is to evaluate the demethylating and tumor suppressor-reactivating activity of hydralazine and procainamide. EXPERIMENTAL DESIGN MDA-231, MCF-7, and T24 cell lines were treated for 5 days with 10 micro M hydralazine or 10 micro M procainamide. 5-aza-deoxycytidine at 0.75 micro M was used as positive control. BALB/c nu/nu mice xenografted with MDA-231 cells we...

BACKGROUND Use-dependent effects of antiarrhythmic drugs on phase 0 sodium current result in rate-dependent conduction slowing with important potential clinical consequences. The purpose of the present study was to determine whether state-dependent interactions of procainamide with sodium channels can be analyzed based on conduction changes in vivo. METHODS AND RESULTS Procainamide infusions ...