This paper presents a novel approach for cyberphysical network control. “Cyber-physical” refers to the inclusion of different parameters and information sources, ranging from physical sensors (e.g. energy, temperature, light) to conventional network information (bandwidth, delay, jitter, etc.) to logical data providers (inference systems, user profiles, spectrum usage databases). For a consiste...

The main protease (Mpro) of severe acute respiratory syndrome coronavirus (SARS CoV) is a key enzyme for viral replication, and is thus an attractive target for anti-SARS CoV drug development. Mpro belongs to the family of 3C-like cysteine proteases. The basic design of peptidomimetic inhibitors involved a warhead that can form covalent modifications to the –SH group of the active site residue ...

Introduction Juvenile Systemic Lupus Erythematous (JSLE) is characterised by auto-antibody production directed against nuclear auto-antigens. Toll-like receptors (TLRs) are pattern recognition receptors of the innate immune system responsible for initiating an immune response against invading pathogens. TLR 3, 7-9 have been studied in SLE due to their unique ability to detect nuclear antigen. T...

In our related work, we proposed Auto Focus for stereo camera. Instead of moving optical axis Cognitive Stereo Auto Focus shifts one side image to the o side for setting focus. In the shifting process, be set on the proper place not to cause any side by visual fatigue to user. To perform low visual fatigue focusing, Cognitive Stereo Auto Focus analyzes the input scene and find how many objects ...

Mammalian cell-based bioprocesses are used extensively for production of therapeutic proteins. Off-line monitoring of such cultivations via manual sampling is often labor-intensive and can introduce operator-dependent error into the process. An integrated multi-functional off-line analyzer, the BioProfile FLEX (NOVA Biomedical, Waltham MA) has been developed, which combines the functionality of...

MOTIVATION In a gene regulatory network, genes are typically regulated by transcription factors (TFs). Transcription factor activity (TFA) is more difficult to measure than gene expression levels are. Other models have extracted information about TFA from gene expression data, but without explicitly modeling feedback from the genes. We present a state-space model (SSM) with hidden variables. Th...

Auto Completion is the facility provided by most modern Integrated Development Environments and source code editors for word completion when editing source code. All auto completion mechanisms that we know of use syntactic knowledge of the programming language to provide this feature. We investigate the use of programming language agnostic prediction models to provide auto completion. We implem...

A demonstration environment is being developed at the Auto-ID Centre in Cambridge, in order to show the benefits of Auto-ID technology when applied to manufacturing control systems. In this paper, the second phase of development is examined. The first phase combined conventional control with Auto-ID information. This phase specifically looks at how Auto-ID facilitates a distributed Holonic Manu...

BACKGROUND Following myomectomy, postoperative adhesions occur in many patients with adverse effects on fertility. This study investigated the applicability, safety and efficacy of an auto-crosslinked hyaluronan gel in preventing adhesion formation after laparoscopic myomectomy. METHODS Fifty-two patients aged 22-42 years, undergoing surgery at four centres, were randomly allocated to receive...

Intraday volatility and market impact models in volume time are proposed. We build an intraday volatility profile to capture non-stationarity of intraday price returns and utilize a fractional Brownian motion process to measure deviations from square root scaling rule of volatility. We propose a generalized, scalable market impact model that encompasses two mainstream approaches: an aggregated ...