Ribosome profiling or ribo-seq is a new technique that provides genome-wide information on protein synthesis (GWIPS) in vivo. It is based on the deep sequencing of ribosome protected mRNA fragments allowing the measurement of ribosome density along all RNA molecules present in the cell. At the same time, the high resolution of this technique allows detailed analysis of ribosome density on indiv...

Developers use various methods and approaches to find bugs and performance bottlenecks in their programs. One of the effective and widely used approach is application profiling by dynamic instrumentation. There are many various tools based on dynamic instrumentation. Each tool has its own benefits and limitations what often forces developers to use several of them for profiling. For example, in...

Kinase profiling during drug discovery is a necessary process to confirm inhibitor selectivity and assess off-target activities. However, cost and logistical limitations prevent profiling activities from being performed in-house. We describe the development of an automated and flexible kinase profiling workflow that combines ready-to-use kinase enzymes and substrates in convenient eight-tube st...

Metabolic profiling of biological samples is increasingly used to obtain more insight into the pathophysiology of diseases. For translational studies, biological samples from animal models are explored; however, the volume of these samples can be a limiting factor for metabolic profiling studies. For instance, only a few microliters of urine is often available from small animals like mice. Henc...

Recommendation system is a type of information filtering systems that recommend various objects from a vast variety and quantity of items which are of the user interest. This results in guiding an individual in personalized way to interesting or useful objects in a large space of possible options. Such systems also help many businesses to achieve more profits to sustain in their filed against t...

We examined whether serum protein profiling is a reliable index for prediction of therapeutic efficacy of preoperative chemoradiotherapy (PCRT) in advanced esophageal cancer compared with evaluation of the efficacy of conventional clinical examination. We entered 42 patients who received PCRT and surgery between 1998 and 2002 into this study. Serum protein profiling was performed using the preo...