The importance of accurate pathological diagnosis is emphasised in the case of a newborn infant who presented with alopecia, a generalised erythrodermatous skin eruption, and hepatosplenomegaly. She subsequently developed generalised lymphadenopathy and recurrent septicaemia and died aged 2 months. The histological findings of widespread lymphocytic, histiocytic, and eosinophilic tissue infiltr...

Kikuchi disease, also called histocytic necrotizing lymphadenitis or focal histiocytic lymphadenitis, is a rare, idiopathic and generally self limited cause of lymphadenitis. It was first described in 1972 in Japan. The most common clinical manifestation is cervical lymphadenopathy with or without systemic symptoms & signs. It almost always runs a benign course and resolves in several weeks to ...

A young male presented with recurrent neck swellings with initial leucocyte count of 16800/mm3, with non-caseating glands on ultrasonography neck. FNAC showed mixed cellularity with histiocytic and marked lymphophagocytosis as seen in Rosai Dorfman Disease. Immunohistochemistry demonstrated CD 25, Ki 67 and CD 68 in histiocytes. Her responded to supportive treatment alone.

Keeling, J. W., and Harries, J. T. (1973). Archives of Disease in Childhood, 48, 350. Intestinal malabsorption in infants with histiocytosis X. An infant with histiocytosis X had unequivocal evidence of intestinal malabsorption which was associated with histiocytic infiltration of the small intestine. 11 other fatal cases where histological material from the gastrointestinal tract was available...

Porcine circovirus type 2 (PCV2) antigen was demonstrated in lungs, lymphoid tissues, intestines, and testes and accessory sex glands of an 11-month-old boar from a boar stud with a history of recent illness and infertility. At necropsy, the lungs failed to collapse and there was moderate cranioventral bronchopneumonia. Microscopically, there was severe multifocal suppurative and histiocytic br...

Erdheim-Chester Disease is a multi-systemic condition characterized by non-Langerhans histiocytic infiltration. Cardiovascular involvement with pseudotumoral infiltration of the right atrium is present in approximately one-third of patients and may be asymptomatic. Although retroperitoneal fibrosis is common, perinephric dystrophic calcification has not been previously described.