Promethazine hydrochloride, a 5-HT3 antagonist is a powerful antiemetic drug with an oral bioavailability of 25% due to extensive hepatic first pass metabolism and is extremely bitter in taste. To overcome the above draw backs, the present study was carried out to formulate and evaluate fast dissolving taste masked wafers of Promethazine hydrochloride for sublingual administration. Taste maskin...

The nausea and vomiting that often accompany early pregnancy may be ameliorated if the patient eats small portions of food at frequent intervals, increases the amount of carbohydrates and decreases the amount of fat, and avoids bothersome food odors. When these strategies fail, antiemetic drugs such as pyridoxine and phosphorated carbohydrate solution may help, as well as doxylamine, promethazi...

The element of control in modern anaesthesia is of special value in ophthalmology, where smooth operating conditions and a trouble-free respiratory period are obligatory. While this feature is of value in controlling bleeding, eye movements, and squeezing, the ability to control intra-ocular tension is of special significance. During operation chlorpromazine, promethazine and pethidine have bee...

A previously well 6 year old boy weighing 18 kg was admitted to hospital with fever and vomiting of 6 days' and increasing drowsiness and haematemesis one days' dura­ tion. He had been treated with paracetamol, oral penicillin, promethazine, haloperidol, phenobarbitone, a brand of paracetamol at a dose of 730 mg three times a day for 3 days (125 mg/kg/day), and an another brand of paracetamol a...

Major use Chlorpromazine hydrochloride (CPH) belongs to antipsychotic drugs, also called neuroleptics; and it is mainly used for the treatment of neurological disorders. CPH has sedative, hypotensive and antiemetic properties. CPH, which is an aliphatic phenothiazine, was first synthesized in 1952. It was extensively studied and used as a model for a big class of neuroleptic agents. Haloperidol...

a multi-walled carbon nanotube modified paste electrode (mwcn-pe) was used for determination of promethazine (pmz) in drug formulations and blood plasma by cyclic voltammetry (cv) and differential pulse voltammetry (dpv) methods. results revealed that the mwcn-pe shows an electrocatalytic activity toward the anodic oxidation of pmz by a marked enhancement in the current response in buffered sol...

Carvedilol (6.25 mg, 4 times daily) relieved 2 years of constant hiccupping, marked tardive dyskinesia, compulsive self-induced vomiting, and feelings of hopelessness and low mood in a 59-year-old African-American man. He previously failed trials of ranitidine, chlorpromazine, promethazine, tegaserod, ondansetron, metoclopramide, pantoprazole, pyloric injections of botulinum toxin A, and a vaga...

BACKGROUND Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ. Systematic reviews show that all relevant studies are small and none are likely to have adequate power to show true differences between treatments. Worldwide, current treatment is not based on evidence from ...