نتایج جستجو برای: propafenone
تعداد نتایج: 393 فیلتر نتایج به سال:
The negative chronotropic effects of eight Vaughan Williams Class I antiarrhythmic drugs were examined in guinea pig right atrial tissue preparations. decreased the spontaneous beating rate at concentrations overlapping with their therapeutic blood levels. Cibenzoline, aprindine, flecainide, and propafenone showed stronger effects; 10 µM each drug to about 75% initial values. Disopyramide, mexi...
Propafenone, a class IC antidysrhythmic drug, is frequently used for pharmacological cardioversion of atrial fibrillation. Using IC antidysrhythmics to reverse recurrent atrial fibrillation is associated with a 3.5–20% incidence of atrial flutter with either ‘‘classical’’ or atypical patterns of atrial activation [1–3]. On the contrary, the appearance of peaked alternating with normal P waves i...
Inhibition of hERG K channels by structurally diverse drugs prolongs the ventricular action potential and increases the risk of torsade de pointes arrhythmias and sudden cardiac death. The capture of drugs behind closed channel gates, so-called drug trapping, is suggested to harbor an increased pro-arrhythmic risk. In this study, the trapping mechanisms of a trapped hERG blocker propafenone and...
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