The effect of propranolol on the electric stimulation of rat isolated diaphragm shOwed the depression of its isometric force of contraction. This depressant effect of propranolol on the rat isolated diaphragm was produced in doses much higher than the doses required for the beta adrenergic receptor blocking activity. Isoprenaline showed no effect on the rat isolated diaphragm and it did not ant...

citric acid and tetracycline hcl are the most common clinical root demineralization agents used in periodontal practice. in this comparative in vitro study the effects of nd: yag laser radiation on root surface was compared to that of citric acid and tetracycline hcl using sem. a total of twenty-one freshly extracted periodontally diseased single rooted premolar teeth were root planned in vitro...

Propranolol, a beta-adrenergic receptor antagonist, also inhibits phosphatidate phosphohydrolase, the enzyme that converts phosphatidic acid into diacylglycerol. This latter effect has prompted recent use of propranolol in studies examining the importance of diacylglycerol and phosphatidic acid in cellular signalling events. Here, we show that propranolol is also an inhibitor of protein kinase ...

OBJECTIVES To report the efficacy of propranolol as first-line treatment of head and neck hemangiomas in children and to present an optimized protocol for treating hemangiomas. DESIGN Multi-institutional retrospective study. SETTING Two tertiary care referral pediatric centers. PATIENTS Thirty-nine children with head and neck infantile hemangiomas were treated. MAIN OUTCOME MEASURES Rev...

INTRODUCTION Recent studies have examined the effectiveness of alpha-2 adrenergic agonists for controlling delirium and agitation. Propranolol, a non-selective beta-adrenergic antagonist with good penetration of the blood-brain barrier, has not been investigated for this purpose. MATERIALS AND METHODS We retrospectively reviewed the medical records of all patients who were prescribed proprano...

Effects of betaxolol, a cardioselective beta-adrenoceptor antagonist, on cardiohemodynamics and coronary circulation were investigated in two kinds of anesthetized open-chest dog preparations in comparison with those of atenolol and propranolol. When administered intravenously, betaxolol, atenolol and propranolol produced dose-dependent decreases in the heart rate (HR), maximum left ventricular...

1. Propranolol, a beta-adrenoceptor blocking drug with local anaesthetic and a direct myocardial depressant action, and MJ 1999, a beta-adrenoceptor blocking drug which has no local anaesthetic or intrinsic sympathomimetic action, were compared for beta-adrenoceptor blocking activity in man.2. Propranolol was 2.67 times more active than MJ 1999 in reducing by 50% the tachycardia produced by the...

The effect of the light schedule on toxic interactions between propranolol and disopyramide were studied in chick embryos. Fertilized eggs of White Leghorns were incubated under dark conditions and investigated, on two occasions, under light conditions or under dark conditions. Propranolol, with and without disopyramide, was injected into the air sac of fertilized eggs on the 16th day of incuba...

background: noradrenaline (na), the principal neurotransmitter released from sympathetic nerve terminals, influences t-cell maturation, not only directly in developing t cells, but also indirectly, by acting on the thymic nonlymphoid cells. in vitro and in vivo studies have demonstrated the anti-proliferative, anti-migratory, antiangiogenic and cytotoxic properties of propranolol, β-ar blocker,...

Experiments are presented to show the effects of (1) propranolol on tbe response of systolic blood pressure and diastolic blood pressure to bilateral carotid artery occlusion in choralose-anesthetized dogs; (2) the effects of propranolol on acute hypertensive states in chloralose-anesthetized dogs; and (3) the effects of propranolol on the response of trained awake dogs to bilateral carotid art...