Leptin, the product of the ob gene, regulates food intake, energy balance and lymphocyte functions. Receptor mutated animals have reduced production of proinflammatory cytokines. To analyze the direct effects of leptin (0.1 nM /1 mM) on cytokine production from colonic cells, we examined pro-inflammatory (IL-8, MCP-1, IL-6 and TNFalpha) and anti-inflammatory (IL-10) cytokine production in norma...

It is well established that the hormone leptin circulates in the plasma in amounts proportional to body fat content and it regulates food intake and body weight via its actions in the hypothalamus. However, numerous studies have shown that leptin receptors are widely expressed throughout the CNS and evidence is growing that leptin plays a role in modulating a variety of neuronal processes. In p...

the aim of this study was to investigate the effect of 12 weeks moderate intensity aerobic exercise on leptin and c-reactive protein serum levels in obese men. the study was conducted in urmia- iran in 2015. twenty-four obese men with an aged range 40-50 yrs. were enrolled into the study. subjects were randomized to one of 2 groups exercise (n=12) and control groups (n=12). the exercise group p...

The leptin regulation of bone remodeling, which has been documented through studies of loss-of-function mutations of this hormone or of its receptor in mice and humans, still raised several unanswered questions. For instance, it has been assumed but not formally demonstrated that this regulation occurs through neuronal means. Likewise, it has not been possible until now to dissociate the influe...

background& objectives: zataria multiflora boiss is used in traditional medicine to treat gastrointestinal disorders and menorrhagia. the inhibitory effect of this herb on rat uterus contractions has also been reported. the aim of this study was to investigate the effect of zataria multiflora boiss hydroalcoholic leaf extract (zhle) on isolated rat ileum in presence of some known ileum stimulan...

Adiponectin is protective against hepatic fibrosis, whereas leptin promotes fibrosis. In HSCs (hepatic stellate cells), leptin signals via a JAK2 (Janus kinase 2)/STAT3 (signal transducer and activator of transcription 3) pathway, producing effects that enhance ECM (extracellular matrix) deposition. SOCS-3 (suppressor of cytokine signalling-3) and PTP1B (protein tyrosine phosphatase 1B) are bot...

Seasonal Siberian hamsters lose fat reserves, decrease body weight and leptin concentrations, and suppress reproduction on short-day photoperiod (SD). Chronic leptin infusion at physiological doses caused body weight and fat loss in SD animals but was ineffective in long-day (LD) hamsters. Using ovariectomized estrogen-treated females, we tested the hypothesis that responsiveness to leptin is r...

OBJECTIVE Melanocortin-4 receptor (MC4R) and agouti-related peptide (AgRP) are involved in energy homeostasis in the rat. The aim of the present study was to evaluate the expression of MC4R and AgRP mRNAs in arcuate nucleus (ARC) during long term malnutrition of female ovariectomized rats. MATERIALS AND METHODS Ten female ovariectomized rats were divided into two equal groups (n=6) of normal ...

Lipid metabolism disorders commonly occur during menopause. Estrogen deficiency has been shown to lead excessive energy intake and abnormal lipid in ovariectomized rats, resulting obesity. Probiotics exhibit anti-obesity properties, their underlying mechanism widely reported. In this study, we demonstrated the metabolic benefits of Lactobacillus plantarum CCFM1180 suppressing appetite, c...