Effect of propylthiouracil (PTU)-induced hypothyroidism during the prepubertal period, at a dose of oneg per kg of the diet, on serum testosterone level and seminal characteristics of Fars indigenous chickens wasstudied. PTU was fed between 7th to 13th weeks of age and semen was collected at weekly intervals, starting at 21st week of age and continued for seven weeks. The effect of PTU treatmen...

MALLOV, SAMUEL, AND ADAWIA A. ALOUSI. Effect of altered cardiac metabolism and work on lipoprotein lipase activity in heart. Am. J. Physiol. 2 I 2 (5) : I I 58-1 I 64. I g67.-Increased cardiac metabolism and/or work were induced in rats by: a) chronic administration of 2 ,4-dinitrophenol, b) aortic constriction, and c) production of hypertension with deoxicorticosterone (DCA) and salt. Decrease...

PURPOSE The objective of this pilot study was to determine the prevalence of coronal dental caries among children with different genetic sensitivity levels of taste, as determined by 6-n-propylthiouracil (PROP). METHODS Coronal caries and restorations in permanent and primary dentition were evaluated in 150 healthy school-aged children aged 6 to 12 years. A filter paper containing 6-n-propylt...

OBJECTIVE Excess iodine and some iodine-containing compounds are known to affect various parameters of thyroid function. Lecithin-bound iodine (LBI) is a compound which induces involution of an enlarged thyroid. LBI was tested for its ability to affect thyroid ornithine decarboxylase (ODC) activity and apoptosis. METHODS LBI was given orally to propylthiouracil-pretreated rats and the changes...

Deiodinases are major determinants of thyroid hormone tissue availability and disposal. The knowledge of the expression of these enzymes in lower species is important to understand evolutionary and ontogenetic aspects of thyroid hormone action and metabolism. Here we have studied outer ring deiodination in the trout liver using both reverse T3 (rT3) and T4 as substrates. The use of rT3 disclose...