As in most forms of cancer, early diagnosis of prostatic cancer is crucial for a high curability rate. A number of biochemical tests are now available to help identify suspected prostatic cancer in the patient by measuring the activity of acid phosphatase (EC 3.1.3.2) in the patient’s serum. Multiple forms of human acid phosphatase have been described in different organs, but the richest source...

The aquaporin (AQP) families of water channels are intrinsic membrane proteins that facilitate selective water and small solute movement across the plasma membrane. The purposes of this study were to determine the expression and localization of AQPs in benign prostatic hyperplasia and prostate cancer. Prostatic tissue was collected from patients with benign prostatic hyperplasia or prostate can...

Prostatic parenchymal calculi are common, usually incidental, findings on morphological examinations. They are typically asymptomatic and may be present in association with normal glands, benign prostatic hyperplasia, and prostate cancer. However giant prostatic calculi are rare. Less than 20 cases have been reported in the literature. We present the case of a 35-year-old man with two giant pro...

Over the last 30 years the death rate from prostatic cancer in Scotland has remained at about 17 per 100,000 in the age group 55-64 years, but at age 65-74 years the rate has increased from 64 in1930-32 to 106 per 100,000 in 1963, and in men aged 85 and over the rate has gone up from 86 to 476 per 100,000 in the same period (Registrar General for Scotland, 1963). This steep rise in mortality in...

In previous studies, we have demonstrated that androgen ablation-induced growth inhibition of androgen-responsive PC-82 and A-2 human prostate cancer xenografts involves not only direct activation of programmed (apoptotic) death of these cells but also indirect activation of this death process via a decrease in tumor angiogenesis secondary to a reduction in tumor vascular endothelial growth fac...

Introduction: Prostate cancer is the second common malignancy in men. Prostatic intraepithelial neoplasia (PIN) precursor lesion of prostatic carcinoma. Histopathological examination necessary to diagnose PIN lesions. Objective: The aim study determine incidence and analyse usefulness basal cell marker p63 expression various lesions prostate. Methods: This a two-year prospective 65 transurethra...

PURPOSE We examined rebiopsies in MUSIC (Michigan Urological Surgery Improvement Collaborative) to understand adherence to guidelines recommending repeat prostate biopsy in patients with multifocal high grade prostatic intraepithelial neoplasia or atypical small acinar proliferation. MATERIALS AND METHODS We analyzed data on men undergoing repeat biopsy, practice patterns and cancer detection...

Linomide (N-phenylmethyl-1,2-dihydro-4-hydroxyl-1-methyl-2-oxo-quinoline-3- carboxamide) is a quinoline 3-carboxamide which previously has been demonstrated to produce immunomodulator and antitumor effects when given in vivo. To test the possible antitumor effects of linomide against prostatic cancers, rats bearing five distinct Dunning R-3327 rat prostatic cancer sublines were treated daily wi...