In order to evaluate the significance of repeat transurethral resection (TUR) in differentiating stage A1 prostatic adenocarcinoma from those with stage A2, we performed repeat TUR in 34 patients with an initial diagnosis of stage A1 prostatic adenocarcinoma. It was found that residual adenocarcinoma was present in five cases (14.7%), but the diagnosis was changed from stage A1 to stage A2 in o...

A man aged 77 presented with nodules on the glans penis. Histological examination confirmed the diagnosis of metastases of prostatic carcinoma.

We reported localized amyloidosis involving seminal vesicles and vasa deferentia, which was found in two patients with prostatic adenocarcinoma. A 60-yr-old (Case 1) and a 59-yr-old (Case 2) man came to our hospital with elevation of serum prostate-specific antigen (PSA) and biopsy proven carcinoma, respectively. MRI revealed multiple irregular foci of low signal intensity in the prostates as w...

1 OBJECTIVE: The purpose of this study is to evaluate the extent and type of atrophy 2 lesions, according to classification proposed by Working group in radical prostatectomy 3 specimens obtained from patients with prostatic carcinoma and benign prostatic hyperplasia 4 (BPH) and compare prevalence and types of atrophy between two investigated groups. 5 METHODS: The total of 1096 slides from 50 ...

A novel gene,/? 73, encoding a protein with significant homology top53, was recently identified at Ip36. To investigate penetrance of p 73 in prostatic carcinogenesis, mutation, allelotyping, and transcription analy ses of p73 were performed in prostatic carcinoma. No types of mutation causing amino acid substitutions or frameshifts were found in 106 cases examined. Loss of heterozygosity in th...

A novel gene,/? 73, encoding a protein with significant homology top53, was recently identified at Ip36. To investigate penetrance of p 73 in prostatic carcinogenesis, mutation, allelotyping, and transcription analy ses of p73 were performed in prostatic carcinoma. No types of mutation causing amino acid substitutions or frameshifts were found in 106 cases examined. Loss of heterozygosity in th...

Two cases of malakoplakia of the prostate are documented, bringing the total described in the world literature to 15. This literature is reviewed, and typical features of the condition are established. The majority of the cases have had proven previous episodes of Escherichia coli infection of the urinary tract, but bacilliform organisms have yet to be demonstrated in the diseased prostatic tis...

Lung cancer metastases to the prostate are uncommon, and are usually found incidentally during autopsy. This case report describes a 77-year-old man with a large cell neuroendocrine carcinoma (LCNEC) of the lung and metastases from this primary cancer in the prostate. During the follow-up after the chemotherapy performed for pulmonary LCNEC, pelvic computed tomography revealed a prostatic tumor...

We compared electrophoretic evaluation of acid phosphatase isoenzymes with spectrophotometric determination of prostatic acid phosphatase in terms of clinical utility. In all of 33 cases of prostatic carcinoma, an increased prostatic fraction was detected; in nine prostatectomized patients, this fraction returned to normal as measured by either technique. Abnormal spectrophotometric results wer...

Genetic changes in epithelial cells initiate the development of prostatic adenocarcinomas. As nascent tumors grow and undergo progression, epithelial tumor cells are intimately associated with stromal cells. Stromal cells within the tumor microenvironment acquire new properties, including the capacity to promote phenotypic and genetic progression in adjacent epithelial cells. Affymetrix microar...