In 38 cases of prosthetic valve endocarditis, 19 were early cases (onset < 60 days after insertion of prosthesis) and 19, late cases (onset> 60 days). Nine late cases had onsets 12 to 53 months after surgery. The sources or predisposing factors in late cases included dental disease or manipulation; genitourinary tract procedures; and skin, urinary, or wound infections. In contrast, most early c...