In this study, we report the synthesis of two new copper complexes: [Cu(C11H7O2)(SCN)(C10H8N2)], denoted as (C-1), and [Cu(C11H7O2) (C12H8N2) Cl]·H2O, (C-2). They are based on 2,2′-bipyridine or 1,10-phenanthroline 2-hydroxy-1-naphtaldehyde ligands. The obtained complexes were characterized by FT-IR, UV-visible spectroscopy, single-crystal X-ray diffraction analysis. Molecular docking was emplo...

Abstract In this research, the impacts of various enzymes (phospholipase-A 2 (0.3% v/v), lipase (0.03% w/v), and protease (0.5% w/v)) on physico-chemical functional characteristics treated egg white protein (EWP) were determined. The pH, turbidity, colour (L*, a*, b*, ∆E*), gas concentrations in package, relative foaming capacity (RFC), stability analysed during storage at 4 °C. (1,000 ± 60.82)...

Structural origin of substrate-enzyme recognition remains incompletely understood. In the model enzyme system of serine protease, canonical anti-parallel beta-structure substrate-enzyme complex is the predominant hypothesis for the substrate-enzyme interaction at the atomic level. We used factor Xa (fXa), a key serine protease of the coagulation system, as a model enzyme to test the canonical c...

Cathepsin B is a lysosomal cysteine protease, contributing to vital cellular homeostatic processes including protein turnover, macroautophagy of damaged organelles, antigen presentation, and in the extracellular space, it takes part tissue remodeling, prohormone processing, activation. However, aberrant overexpression cathepsin its enzymatic activity associated with different pathological condi...

The protease from simian immunodeficiency virus (SIV) was chemically synthesized by automated solid-phase technology as an NH2-terminally extended derivative, capped with biotin. Biotin-linker-(SIV protease (1-99)): the linker segment, Gly-Gly-Asp-Arg-Gly-Phe-Ala-Ala, corresponds to the amino acid sequence preceding that of the protease in the SIV gag/pol precursor polyprotein. Accordingly, the...

Objective: The present study aimed to evaluate those 3 compounds among 122 Thai natural products by using a molecular docking approach inhibit Main Protease (Mpro) of SARS-CoV-2 (PDB code: 6Y2F), Angiotensin Converting Enzyme (ACE)-2 1R4L), and PAK-1 kinase 5DEW).
 Methods: evaluation was performed on the scores calculated AutoDock Vina as engine interaction profile analysis through 2-dime...

The study included the collection of a sample 80 patients reviewers for consulting eyes in Numan Teaching Hospital, injured eye infections ages ranged from (70-5) males and females, Results showed first examination that 68 samples by 85 % been positive bacterial growth either 12 was negative accounted 15%. results sovereignty staphylococcus aureus 32.05 %. varied sensitivity assay over isolates...

The objective of this study was focussed on phytochemical screening, in vitro antioxidant and antiprotease activities various solvent extracts Muehlenbeckia platyclada root. roots were washed thoroughly, shade dried coarsely powdered. powdered material successively extracted with hexane, chloroform methanol using soxhlet apparatus. Preliminary screening for carbohydrates, proteins, alkaloids, p...

A trypsin-like protease was purified from spent culture medium of oral pathogen Porphyromonas gingivalis by chromatography on columns of DEAE-Sepharose, gel filtration on Sephadex G-100, and chromatofocusing on PBE-94. Purified enzyme showed a single band on SDS-polyacrylamide gel electrophoresis with an estimated molecular weight of 55,000. Purified protease hydrolyzed type I, III, IV, and V c...