How to feed an enzyme ethane When released from ocean floor seeps, small hydrocarbons are rapidly consumed by micro-organisms. Methane is highly abundant and both produced microbes through well understood biochemical pathways. Less how ethane, also a major natural component of gaseous hydrocarbons, metabolized. To understand take advantage this energy carbon source, Hahn et al. solved the x-ray...

An unexpected observation among the COVID-19 pandemic is that smokers constituted only 1.4%–18.5% of hospitalized adults, calling for an urgent investigation to determine role smoking in SARS-CoV-2 infection. Here, we show cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger protein catabolism. BaP induces aryl hydrocarbon receptor (AhR)-dependent upr...

Only turnover studies can reveal the mechanism behind an abnormal serum concentration of a given protein. Albumin, the major fraction of serum protein, is usually low when total serum protein is low and hence basic causes of hypoproteinaemia are much the same as those of hypoalbuminaemia: (1) increased catabolism which occurs in a variety of acute conditions such as acute infections, trauma inc...

A method for the simultaneous measurement of gastrointestinal protein loss and total albumin turnover entailing the use of a combination of (125)iodine- and (51)chromium-labeled albumin is described. Albumin turnover was calculated by the measurement of albumin-(125)I plasma decay and cumulative urinary excretion, and the results obtained agreed closely with previous studies utilizing albumin-(...

Background: General anesthesia using remifentanil may suppress the unwanted metabolic changes caused by surgical stress including hyperglycemia and ketogenesis. Surgery-related changes in catabolism can be attenuated with low-dose glucose load, without causing hyperglycemia. However, the impact of glucose load in diabetic patients during surgery is unknown. In this study, we investigated the ef...

UNLABELLED CCAAT enhancer binding protein α (C/EBPα) plays an essential role in cellular differentiation, growth, and energy metabolism. Here, we investigate the correlation between C/EBPα and hepatocellular carcinoma (HCC) patient outcomes and how C/EBPα protects cells against energy starvation. Expression of C/EBPα protein was increased in the majority of HCCs examined (191 pairs) compared wi...

In normal man there is a fine balance between anabolic and catabolic processes. Both are under hormonal control, with insulin acting as the prime anabolic agent and a group of hormones, glucagon, the two catecholamines and glucocorticoids, regulating catabolism. Growth hormone has a mixed anabolic and catabolic function directed primarily at amino acid and protein conservation. Recently there h...

1. Measurements were made of the nitrogen and energy balances of pigs of 30, 60 and 90 kg given a conventional diet at various daily rates. 2. Body protein synthesis was estimated from the irreversible loss of leucine from the blood following the infusion of [1-14C]leucine, and from the oxidation of the labelled amino acid. 3. Protein synthesis (g/d) increased by 2.17 for each 1 g increase in ...