The Breakpoint Cluster Region is a protein encoded by the BCR gene with its partially discovered function to generate instructions for producing and also encode serine/threonine kinase protein. There are three cluster regions; major (M-bcr) which high in CML patients, minor (m-bcr) 1-2% contribution CML, micro (μ-bcr) very rare case of CML. ABL1 encodes can as tyrosine kinase. translocation ABL...

To investigate the role of gallic acid in lipopolysaccharide/interferon-gamma induced macrophage polarization toward M1. Macrophages were isolated from peritoneal wash fluid and exposed to prepared at concentrations control, 6.25, 12.5, 25 37.5 μg/ml, presence lipopolysaccharide interferon-gamma, for establishment M1 polarization. Adenosine 5’-monophosphate-activated protein kinase inhibitor co...

as an aromatic and colorful plant of substantive taste, saffron (crocus sativus l.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. regarding the critical role of micrornas in secondary metabolic synthesis and the limited number of identified mirnas in c. sativus, on the other hand, one may see the point how the characte...

As an aromatic and colorful plant of substantive taste, saffron (Crocus sativus L.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. Regarding the critical role of microRNAs in secondary metabolic synthesis and the limited number of identified miRNAs in C. sativus, on the other hand, one may see the point how the characte...

Long-term potentiation (LTP) is a form of activity dependent plasticity that induced by high-frequency stimulation or theta burst stimulation and results in synaptic transmission. Several Studies have been shown that LTP is one of the most important processes in the CNS that plays an important role in learning and memory formation. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major...

Background: Salivary gland tumors (SGT) are rare lesions with uncertain histopathology. One of the major signaling pathways that participate in the development of several tumors is protein kinase A. In this pathway, glycogen synthase kinase β (GSK3β) and cAMP responsive element binding protein (CREB3) are two genes which are supposed to be down regulated in most human tumors. The expression lev...

Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of eupafolin on LPS-induced cardiomyocyte autophagy...

Prostate cancer (PCa) is the most common type of cancer among men over 60 years old. The aggressiveness and mortality of PCa can be correlated with obesity. Adipose tissue-derived cytokines such as adiponectin may explain the correlation between PCa and obesity. Since the correlation between adiponectin and aggressive PCa is still not fully evaluated, we aimed to investigate the probable role o...

Objective(s): Present study investigated the neuroprotective effects of selegiline and the molecular mechanisms involved in methamphetamine-induced neurotoxicity.Materials and Methods: Male wistar rats were randomly divided into six groups (10 rats in each group). Group 1 and group 2 received normal saline and methamphetamine (10 mg/kg),...