نتایج جستجو برای: proteoglycans
تعداد نتایج: 5818 فیلتر نتایج به سال:
OBJECTIVES Alteration in the composition of extracellular matrix has been suggested as the major factor for the development of tendinopathy and calcified tendinopathy, which has poorer clinical manifestation. This study investigated the changes of major proteoglycans and collagens in a calcified tendinopathy model and correlated the expression with the acquisition of chondrocyte phenotype, ecto...
Proteoglyeans from bovine aorta were extracted by 0.15 M NaCl and by digestion with collagenase and with elastase. The nonspecific protease activity of elastase was inhibited by soybean trypsin inhibitor. Glycosaminoglycans (GAG) of the proteoglycans were isolated, characterized, and quantitated. About 50% of the tissue chondroitin 4and B-sulfates, 75% of hyaluronic acid, and almost all chondro...
Proteoglycans are associated with the initiation of atherosclerosis due to their binding of apolipoproteins on lipid particles leading to retention in the vessel wall. The signaling pathways through which growth factors regulate the synthesis and structure of proteoglycans are potential therapeutic targets. Platelet-derived growth factor (PDGF) is present in atherosclerotic plaques and activate...
Sonic hedgehog promotes proliferation of developing cerebellar granule cells. As sonic hedgehog is expressed in the cerebellum throughout life it is not clear why proliferation occurs only in the early postnatal period and only in the external granule cell layer. We asked whether heparan sulfate proteoglycans might regulate sonic hedgehog-induced proliferation and thereby contribute to the spec...
This issue of Seminars in Cell and Developmental Biology contains a number of articles reviewing the cellular functions of proteoglycans. Proteoglycans are proteins, substituted with glycosaminoglycans (GAGs), that generally either decorate the cell membrane or fill the extracellular space. GAGs are linear polysaccharides consisting of a repeating disaccharide, generally of an acetylated amino ...
The effect of reactive oxygen species on de novo synthesis of heparan sulfate proteoglycans (HSPGs) of the renal glomerulus was investigated in an organ perfusion system. Isolated kidneys were perfused for 7 hr with a medium containing [35S]sulfate to label sulfated proteoglycans or [35S]methionine to label total glomerular glycoproteins. For the generation of reactive oxygen species, xanthine ...
Chondroitin sulfate (CS) proteoglycans are strong inhibitors of structural rearrangement after injuries of the adult CNS. In addition to CS chains, keratan sulfate (KS) chains are also covalently attached to some proteoglycans. CS and KS sometimes share the same core protein, but exist as independent sugar chains. However, the biological significance of KS remains elusive. Here, we addressed th...
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