protonation of the reactive intermediates generated in the raction between dalkyl acetylenedicarboxylates and triphenylphosphine by isonitrosoacetophenone leads to vinyltriphenylphosphonium salts, which undergo intramolecular wittig reaction to produce dalkyl 4-phenyl-n-hydroxypyrrole-2,3-dicarboxylates in moderate yields.

Mycobacteria such as M. tuberculosis represent a significant health concern throughout much of the developing world. In mycobacteria and other pathogenic bacteria, an important virulence factor is the ability of the bacterium to obtain iron from its host. One means of obtaining iron is through the use of siderophores. Brasilibactin A is a membrane bound siderophore produced by Nocardia brasilie...

The sulfonated tripodal polyaza-polycatechol-amine ligand tris(2,3-hydroxy-5-sulfobenzylamine) ethyl)amine (STRENCAT) was synthesized and its protonation constants determined by potentiometry at 25 degrees C and in 0.1 mol dm(-3) NaClO(4). In the adopted experimental conditions (2.5 < p[H(+)] < 11.5), six of the virtual thirteen protonation constants of STRENCAT were determined. The deprotonati...

Physico-chemical profiling is a fundamental tool at the early stage of drug discovery in screening drug-like candidates. Complex physico-chemical profiling, including molecular properties such as solubility, ionization, lipophilicity and permeability, has been found to be of predictive power in ADME (absorption, distribution, metabolism, elimination). In the present thesis work, the physico-che...

A novel macrocyclic DO3A derivative containing a linear diamine pendant arm, H3do3aNN, was prepared and its protonation and complexation properties were studied by means of potentiometry. It determined ligand consecutive protonation constants log K(An) = 12.62, 10.28, 9.67, 8.30, 3.30 and 1.58 and stability constants of selected lanthanide (Eu(iii), Yb(iii)) complexes log K(EuL) = 23.16 and log...

Abstract Stability and structure of complexes between silver (I) l -methionine (L) deduced from potentiometric 1 H NMR measurements allow to assume the prevailing several protonated species. The experimental data are compatible with formation following complexes: AgL, AgL 2 , AgH L, L 3 4 . coordination sites obtained by spectra, showing that only bond methylthioether sulfur atom is responsible...

The protonation constants of DTPA (diethylenetriaminepentaacetic acid) and two derivatives of DTPA, 1-R(4,4diphenyl cyclohexyl-phosphonyl-methyl diethylenentriaminepentaacetic acid (MS-325) and (R)-hydroxymethyl-diethylenentriaminepentaacetic acid (HMDTPA) were determined by potentiometric titration in 0.1 M NaClO4. The formation of 1 : 1 complexes of Am3+, Cm3+ and Ln3+ cations with these thre...

the complexation reactions between cu2+, pd2+ and ni2+ metal ions with promethazine (pm) in water or dmf were studied by the spectrophotometric methods at [(15, 25,35 and 45±0.1) °c]. the complexation process was optimized in terms of ph, temperature and contact time. the stoichiometry of the complex was found to be 1:1 (metal ion/ligand). the formation constants of the resulting complexes were...

A novel synthesis of 3-fold symmetric, homochiral tris(2-alkyl-2-aminoethyl)amine (TREN) derivatives is presented. The synthesis is general in scope, starting from readily prepared chiral alpha-amino aldehydes. The optical purity of the N-BOC protected derivatives of tris(2-methyl-2-aminoethyl)amine and tris(2-hydroxymethyl-2-aminoethyl)amine has been ascertained by polarimetry and chiral NMR c...