Many DNA lesions cause pausing of replication forks at lesion sites; thus, generating gaps in the daughter strands that are filled-in by post-replication repair (PRR) pathways. In Saccharomyces cerevisiae, PRR involves translesion synthesis (TLS) mediated by Poleta or Polzeta, or Rad5-dependent gap filling through a poorly characterized error-free mechanism. We have developed an assay to monito...

The innate immune system is the first line of defense against invading pathogens. Innate cells recognize microbes via pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs); initiate innate immune responses; and eventually trigger adaptive immunity. Association of heterologous PRRs synergistically enhances their signal intensity. Such PRR clu...

This paper aims at supporting the knowledge engineering process by proposing an approach to map CommonKADS knowledge models into specifications based on the Production Rule Representation (PRR) language. This approach starts by proposing a metamodel of CommonKADS knowledge models. We define the concept of inference group, required to perform the mapping transformations, and an algorithm that id...

The innate immune system provides the first line of defence against infection. The main molecules involved in recognizing invading pathogens are the Pattern Recognition Receptors (PRRs). They invoke inflammatory responses to eliminate infection. To avoid excessive inflammation and to prevent tissue damage, signalling of these receptors needs to be under stringent control. MicroRNAs (miRNAs) hav...

INTRODUCTION Fishing communities (FCs) in Uganda have high HIV infection rates but poor access to health services including family planning (FP). Although FP is a cost-effective public health intervention, there is a paucity of data on knowledge and use of modern FP in FCs. This study determined knowledge and use of modern FP methods in FCs of Uganda. METHODS Data were accrued from a 12-month...

In the lateral intraparietal area (LIP), a saccaderelated region of the posterior parietal cortex (PPC), spiking activity recorded during the memory period of an instructed-delay task exhibits temporal structure that is spatially tuned. These results provide evidence for the existence of ‘dynamic memory fields’ which can be readout by other brain areas, along with information contained in the m...

Proton relaxation rate (PRR) studies indicated that there was little direct interaction between manganous ion and adenylate kinase. However, a large enhancement of the PRR of water was observed in the presence of ATP; for the enzyme combined with manganous-ATP complex rather than directly with the metal ion. Thus adenylate kinase is similar to creatine kinase but not to pyruvate kinase, with re...

BACKGROUND Propranolol hydrochloride, one of the most widely used beta-blocker in the treatment of hypertension since 1960s, shows a number of serious and non-serious adverse events. OBJECTIVE Major objectives of this study were to extract the Canadian Adverse Drug Reaction Monitoring Program (CADRMP) database for possible toxic signal detection (SD) of propranolol hydrochloride, evaluate the...

BACKGROUND Some ligands of pattern recognition receptors (PRR) are present on tumour cells. The role of PRR in signalling for cytokine and reactive oxygen intermediates (ROI) production by monocytes and monocyte-derived macrophages (MDM) stimulated with tumour cells was studied. MATERIALS AND METHODS Monocytes/MDM were pretreated with PRR ligands or anti-PRR monoclonal antibodies (mAbs) and s...

OBJECTIVE To estimate the individual and combined associations of physical and psychosocial working environment with disabling shoulder pain and to identify groups at "high risk" for shoulder pain. METHODS A cross sectional survey was conducted at five manual occupational settings in south Manchester, United Kingdom (n=775, 83%). RESULTS Both the duration of occupational physical demands (w...