In order to study the prevalence of psoriatic arthritis in Imam Reza Hospital and determine the effects of factors like age, sex, familial history, type of skin involvement, nail involvement and duration of disease on psoriatic arthritis, 300 psoriatic patients over a period of 4 years were admitted and examined in the Department of Dermatology and Rheumatology in Imam Reza Teaching Hospita...

Psoriasis is a common inflammatory skin disorder with strong impact on patients’ QOL. The most psoriasis form, vulgaris (PsV), characterized by demarcated, erythematous, raised plaques along silvery scales. Up to 30% of patients PsV develop an joint disease named psoriatic arthritis (PsA) (Mease et al., 2013; Reich 2009). and PsA are genetically complex diseases >65 susceptibility loci identifi...

Psoriasis vulgaris is a chronic cutaneous inflammatory disease. Our previous study showed that enhanced M1 macrophage infiltration in the psoriatic skin was obliterated by successful clinical treatment. WNT signaling known to regulate activation and polarization. We aimed investigate how signal pathways polarization psoriasis, if so, TNF-α blockage would subvert aberrant via specific signals. i...

scientific evidence regarding the efficacy and safety of the ldm approach in the treatment of psoriasis vulgaris, and positive preliminary data regarding the oral administration of low dose activated cytokines for vitiligo and atopic dermatitis treatment, support the ldm-based therapeutic approach for many dermatological diseases. ldm suggests the use of low-doses of activated biological molecu...

Severe cutaneous drug reactions include a wide spectrum of clinical manifestations ranging from mild morbilliform cutaneous rash, to severe forms of hypersensitivity. Special attention is given in this report to the acute generalized exanthematous pustulosis (AGEP), induced in 90% of cases by the use of systemic drugs, especially aminopenicillins and macrolides. The incidence of the disease is ...

Psoriasis is one of the most common skin diseases. The mainstay of treatment for the vast majority of patients is topical therapy. A rising first-line treatment modality for psoriasis vulgaris is the two-compound ointment containing calcipotriol 50 mug/g plus betamethasone dipropionate 0.5 mg/g (Dovobet((R)), Daivobet((R)), Taclonex((R))), which combines a vitamin D analog and a corticosteroid....

Psoriasis is a chronic skin disease characterized by abnormal keratinocyte proliferation and differentiation, inflammation, and angiogenesis. Overexpression of tribbles homolog3 (TRB3), which belongs to the tribbles family of pseudokinases, has been found in several human tumors and metabolic diseases, but its role in psoriasis has not been fully clarified. The aim of this study is to investiga...

Psoriasis is a multifactoral and heterogenetically inherited disease. The role of hereditary transmission is supported by familial association, twin studies, and correlation with human leukocyte antigens (HLA). Numerous studies have proved that B13, B17, Cw6, and DR7 antigens are positively associated with psoriasis. Cw6 antigen has been repeatedly indicated to be the most significant marker fo...

Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation of Toll-like receptors (TLRs) 7, 8 and 9 contributes to the initiation and maintenance of psoriasis. We have evaluated the effects of TLR antagonists on the gene expression profile in an IL-23-induced skin inflammation model in mice. Psor...

BACKGROUND Severe psoriasis vulgaris can be extremely difficult to treat in some patients, even with the newer biological therapies available today. CASE PRESENTATIONS We present two patients with severe chronic plaque psoriasis who received numerous systemic anti-psoriatic therapies with varied results. Both responded well to initial treatment with efalizumab (anti-CD11a), but then experienc...