Andropause, a syndrome in aging men, consists of physical, sexual, and psychologic symptoms that include weakness, fatigue, reduced muscle and bone mass, impaired hematopoiesis, oligospermia, sexual dysfunction, depression, anxiety, irritability, insomnia, memory impairment, and reduced cognitive function. Free testosterone levels begin to decline at a rate of 1% per year after age 40 years. It...

Psychologic distress is associated with increased lung cancer incidence and mortality. We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of β-adrenergic receptors and that this pathway is inhibited by the neu...

stress and aDxiety have long been known many bodily fUDctions. Psychologic stress marked increase in catecholamine release from the adrenal medulla, iDcreased sympathetic nervous system activity, and changes in circulating levels of adrenocortical and other hormones. The early psychosomat literature suggests that epinephrine is elaborated duriDg ar, whereas norepine phrine is elaborated during ...

The collective of endocrine organs acting in homeostatic regulation-known as the hypothalamic-pituitary-adrenal (HPA) axis-comprises an integration of the central nervous system as well as peripheral tissues. These organs respond to imminent or perceived threats that elicit a stress response, primarily culminating in the release of glucocorticoids into the systemic circulation by the adrenal gl...

BACKGROUND This study examines the impact of pulmonary hypertension (PH) on the quality of life (QoL) of affected youth, as well as the relationships among PH disease severity, parental adjustment variables, and family relational functioning. METHODS Subjects were 47 eligible parents of children with PH aged 2 to 18 years who were evaluated at Boston Children's Hospital. Measures of patient Q...

Triazolam was used to study the plasma concentration-effect relationship of a benzodiazepine because it has a very short plasma t1/2. A standard hypnotic dose of 0.25 mg was given by mouth to six healthy subjects, and blood samples were drawn when the subjects had to perform a battery of psychologic tests. Only the digit-symbol substitution test, the card-sorting test according to numbers, and ...

e developing fetus is a€ected by social and environmental inuences, including maternal nutritional status; substance use (both legal and illicit); and psychologic trauma. Correspondingly, the psychologic alterations experienced by the parents during the gestation profoundly impact the lives of all members of the family. Growing evidence implicates the importance of these and other maternal an...

Issues concerning the safety and effectiveness of treatment of not guilty by reason of insanity (NGRI) patients in the community have come under increased public scrutiny and professional discussion in recent years. I Despite the intensity of controversy in this area, few objective data exist relative to these concerns. Thus, meaningful decisions regarding safe and effective treatment of the NG...