PEDIATRICS Vol.53 No.4ApriI 1974 for all. Its very emergency nature may at times add trouble since the tendency may be to overdose. It should be kept in mind that harm can be done by overtreating a patient in status epilepticus, particularly when using the longer-acting drugs. The comatose state frequently accompanying status epilepticus can be worsened by the cumulative effect of too frequent ...

Both ethanol and benzodiazepines impair psychomotor function. Previous work has suggested that ethanol may have a greater effect on errors while benzodiazepines may cause greater slowing, but this has not been tested in a direct comparison. We assessed the effects of ethanol, at blood concentrations of approximately 80-100 mg/100 ml, compared to two doses of temazepam (20 mg and 30 mg) on psych...

High density of cannabinoid receptors type 1 (CB1) in the brain suggests that endocannabinoid system plays an important role in the functioning of the central nervous system. Natural and synthetic cannabinoids are known to attenuate learning and memory processes. The adverse effects of cannabinoids are reversed by SR141716A, at first reported to be a selective CB1 receptor antagonist, later sho...

BACKGROUND Carpal tunnel syndrome (CTS) is a major occupational illness in the US. The Wisconsin Test is a quantitative computer-controlled test battery designed for measuring sensory and psychomotor function. Subjects were recruited from industrial jobs at high-risk for CTS to determine if subtle sensory and motor deficits were observable in a working population. Outcomes were studied for pote...

People suffering from multiple chemical sensitivity (MCS) complain of a variety of symptoms that could impair cognitive and psychomotor function either directly or indirectly. This paper discusses the use of cognitive and psychomotor performance tests together with some experiment designs that could be considered for use to assess fitness of MCS sufferers for work or the efficacy of diagnostic,...

OBJECTIVE The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children. METHODS As part of an ongoing prospective cohort study in an inner-city minority population, neurotoxicant effects of prenatal exposure to chlorpyrifos were evaluated in 254 children through the first 3 year...

BACKGROUND AND AIMS Melatonin (MT), a naturally occurring pituitary hormone has a sleep promoting effect. There are very few studies on pre-operative oral MT (0.2-0.5 mg/kg) in children. We planned a study to assess the efficacy of oral MT in two doses and compare it with oral midazolam and placebo for pre-operative anxiolysis, sedation, maintenance of cognition and psychomotor skills, parental...

OBJECTIVE To investigate possible correlations between the tendency towards alexithymia and the depressive state, globally and with regard to the Toronto Alexithymia scale (TAS-20) subscales and the Hamilton rating scale for depression (HAM-D) subscales. METHODS 75 patients, suffering from Unipolar Depression, were assessed through the HAM-D and the TAS-20 and compared to the control group (n...

introduction : tardive dyskinesia is one of the major side effects of long-term neuroleptic treatment. increased reactive oxygen species and oxidative stress has been proposed as possible etiopathologic mechanisms. ginkgo biloba extract (egb) is a natural antioxidant. we investigated the effects of ginkgo biloba extract on neuroleptic-induced orofacial dyskinesia in rats, a potential animal mod...

Predicting differential antidepressant efficacy remains an elusive goal in major depressive disorder (MDD). The aims of this study were three-fold. Firstly, to examine if psychomotor retardation symptoms (item 8 on the 17-item Hamilton Depression Rating Scale) improve preferentially to venlafaxine (VEN) over escitalopram (ESC) treatment. Secondly, whether the 18 item CORE psychomotor signs scal...