The effect of the hormones triiodothyronine (T3) and melatonin on antioxidant defense system was studied in 6-propyl thiouracil (6-PTU)-treated or photoperiod-exposed teleost Anabas testudineus. 6-PTU (2 microg/g) treatment or photoperiod exposure (24 h) increased malondialdehyde (MDA) and conjugated dienes (CD) concentrations, indicating increased lipid peroxidation (LPO) in the experimental c...

To investigate the kinetic parameters of the crossbridge cycle that regulate force and shortening in cardiac muscle, we compared the mechanical properties of cardiac trabeculae with either ATP or 2-deoxy-ATP (dATP) as the substrate for contraction. Comparisons were made in trabeculae from untreated rats (predominantly V1 myosin) and those treated with propylthiouracil (PTU; V3 myosin). Steady-s...

Autoimmune diseases may be related with the development of a secondary autoimmune disorder. We, herein, report a case (31 years old female) of idiopathic thrombocytopenic purpura responding to antithyroid treatment in a patient with Graves Opthalmopathy (GO). The relation between Idiopathic Thrombocytopenic Purpura (ITP) and Graves Disease (GD) is not well known. In the current case, recovery f...

La vasculitis asociada a propiltiouracilo (PTU) y ANCA es una enfermedad rara con incidencia de 0,47-0,71 casos por cada 10 000 pacientes. Afecta principalmente los vasos menor calibre. Piel, riñones pulmones son más afectados. El diagnóstico requiere alta sospecha clínica se apoya en estudios histopatológicos las lesiones piel serología positiva para ANCA. suspensión del medicamento suele bast...

Background: Hypothyroidism is a decrease in the production of thyroid hormones and leads to gland dysfunction. Ashwagandha extract was used as an ayurvedic treatment supposed be antihypothyroidism agent. Objectives: investigate impact ashwagandha (Ash) on propylthiouracil (PTU)-induced hypothyroidism rats. Subjects Methods: The rats were divided into three groups, control group, PTU (hypothyroi...

Glucuronidation of iodothyronines in rat liver is catalyzed by at least three UDP-glucuronyltransferases (UGTs): bilirubin UGT, phenol UGT, and androsterone UGT. Bilirubin and phenol UGT activities are regulated by thyroid hormone, but the effect of thyroid status on hepatic glucuronidation of iodothyronines is unknown. We examined the effects of hypothyroidism induced by treatment of rats with...

Differential effects of propylthiouracil (PTU), methimazole (MMI) and thyroidectomy (Tx) on liver and plasma proteins have been studied in rats, some of which have been simultaneously treated with L-thyroxine (T4). Although the absolute liver weights were lower in all hypothyroid groups, the relative liver weights (g/100 g) were significantly higher in PTU and MMI groups, while in Tx group they...

BACKGROUND Micro-CT (μCT) studies that combine simulated canals with meglucamine diatrizoate to evaluate the shaping ability of nickel-titanium (NiTi) rotary instruments are lacking in the literature. The purpose of this study was to evaluate the shaping ability of three new different nickel-titanium rotary instruments in simulated root canals using μCT. METHODS Thirty simulated root canals w...

Brain-derived neurotrophic factor (BDNF) is a neurotrophin critical for many developmental and physiological aspects of CNS function. Severe hypothyroidism in the early neonatal period results in developmental and cognitive impairments and reductions in mRNA and protein expression of BDNF in a number of brain regions. The present study examined the impact of modest levels of developmental thyro...