Studies in animal models have shown that, following lobectomy (LBX), there is compensatory growth in the remaining lung. The vascular growth response following right LBX (R-LBX) is poorly understood. To test the hypothesis that arterial growth and remodeling occur in response to LBX, in proportion to the amount of right lung tissue removed, two (24% of lung mass; R-LBX2 group) or three right lo...

In mammals, including rats and mice, the development of pulmonary alveolar septa is primarily limited to late gestation and the early periods of postnatal life. Before this time, the rat lung contains a relatively large supply of endogenous retinyl ester that, together with its metabolite retinoic acid, has been shown to increase elastin gene expression and the number of alveoli. We have hypoth...

The small trees of gas-exchanging pulmonary airways, which are fed by the most distal purely conducting airways, are called acini and represent the functional gas-exchanging units. The three-dimensional architecture of the acini has a strong influence on ventilation and particle deposition. Due to the difficulty in identifying individual acini on microscopic lung sections, the knowledge about t...

Le Cras, Timothy D., Lucas G. Fernandez, Patricia A. Pastura, and Victor E. Laubach. Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol 98: 1140–1148, 2005. First published October 29, 2004; doi:10.1152/ japplphysiol.00479.2004.—Studies in animal models have shown that, following lobectomy (LBX), there is compensatory growth in the remaining lun...

This study was conducted at the laboratory of histology and anatomy, Faculty Medical Health Techniques/Kufa, post Graduate/ Department biology, Science/University Kufa, The present to investigate effect Prazosin hydrochloride on some organs in male rats (Rattus norvegicus), about 25 mature with average body weight 210-290gram three months age were randomly divided into four groups (5rats / grou...

Massaro, Gloria D., and Donald Massaro. Retinoic acid treatment partially rescues failed septation in rats and in mice. Am J Physiol Lung Cell Mol Physiol 278: L955–L960, 2000.—Pulmonary alveoli are formed in part by subdivision (septation) of the gas-exchange saccules of the immature lung. Septation results in smaller, more numerous structures (alveoli) and is developmentally regulated in mamm...

Measuring soluble gas in the exhaled breath is a non-invasive technique used to estimate levels of respiratory, solvent, and metabolic gases. The interpretation of these measurements is based on the assumption that the measured gases exchange in the alveoli. While the respiratory gases have a low blood-solubility and exchange in the alveoli, high blood-soluble gases exchange in the airways. The...

The mechanical derangements in the acutely injured lung have long been ascribed, in large part, to altered mechanical function at the alveolar level. This has not been directly demonstrated, however, so we investigated the issue in a rat model of overinflation injury. After thoracotomy, rats were mechanically ventilated with either 1) high tidal volume (Vt) or 2) low Vt with periodic deep infla...