BACKGROUND The objective was to determine if intraoperative pulmonary artery (PA) flow studies after complete unifocalization correlate with postrepair hemodynamics for pulmonary atresia (PA), ventricular septal defects (VSD), and major aortopulmonary collaterals. METHODS AND RESULTS Twenty patients (median age, 8 months; weight, 7.9 kg) underwent unifocalization between 2003 and 2008. A func...

To determine the frequency and correlates of pulmonary hypertension in sleep-disordered breathing, pulmonary artery pressure, lung function and arterial blood gases were measured in 100 consecutive patients with obstructive sleep apnoea (OSA) (respiratory disturbance index (RDI) of > 20 episodes.h-1). Twenty six of the patients had significant chronic airflow limitation (CAL). Overall, 42% of p...

ABBREVIATIONS : AHI 5 apnea-hypopnea index ; BNP 5 B-type natriuretic peptide ; CRP 5 C-reactive protein ; CSA 5 central sleep apnea ; CSR 5 Cheyne-Stokes respiration ; CTEPH 5 chronic thromboembolic pulmonary hypertension ; IPAH 5 idiopathic pulmonary arterial hypertension ; LV 5 left ventricular ; mPAP 5 mean pulmonary artery pressure ; NPV 5 negative predictive value ; OHS 5 obesity hypovent...

OBJECTIVE To investigate the influence of Fasudil, a Rho inhibitor on the number and functions of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. BACKGROUND It is not clear yet, whether Rho Kinase Inhibitor Fasudil can reduced pulmonary artery pressure through improving lung endothelial fun...

BACKGROUND Acute right ventricular overload is associated with high morbidity and mortality clinical situations such as: extensive lung resection, pulmonary thromboembolism, lung transplantation and high altitude pulmonary edema. Some points of its pathophysiology remain unclear. OBJECTIVE To assess the hemodynamic effects of experimental acute right ventricular overload in pigs. METHODS Ri...

OBJECTIVES To determine the effect of differing modes of left ventricular assist device (LVAD) operation: synchronous, independent (asynchronous or pseudosynchronous) or counter pulsation (antisynchronous), on left atrial pressure, pulmonary artery pressure, pulmonary blood flow and right ventricular work load, utilizing a previously published electrical analogy of the systemic and pulmonary ci...

We aimed to characterise the association of pulmonary hypertension due to hypoventilation and exercise capacity, and the haemodynamic and functional changes under noninvasive ventilation. A retrospective analysis was carried out to assess haemodynamics and functional capacity in 18 patients with daytime pulmonary hypertension, due to hypoventilation, at baseline and after 3 months of noninvasiv...