Citation: Mitsiadis TA and Woloszyk A (2015) Odyssey of human dental pulp stem cells and their remarkable ability to survive in extremely adverse conditions. Front. Physiol. 6:99. Adult tissues contain stem cells, which proliferate to compensate for tissue loss throughout the life of the organism (Li and Clevers, 2010; Jiménez-Rojo et al., 2012). Therefore, adult stem cells are important for ti...

Complex human tissues harbor stem cells and/or precursor cells, which are responsible for tissue development or regeneration. Recently, dental tissues such as periodontal ligament (PDL), dental papilla or dental follicle have been identified as easily accessible sources of undifferentiated cells. Dental precursor cells are attractive for usage in regenerative dentistry, like for example regener...

Pulpotomy therapy for the primary dentition has developed along three lines: devitalization, preservation, and regeneration. Devitalization, where the intent is to destroy vital tissue, is typified by formocresol and electrocautery. Preservation, the retention of maximum vital tissue with no induction of reparative dentin, is exemplified by glutaraldehyde and ferric sulfate treatment. Regenerat...

The ultimate aim of endodontic treatment focuses towards the complete preservation of physiologic, structural & mechanical integrity of native pulp – dentin complex. Regenerative endodontic procedure along with tissue engineering can be one of the novel approach to restore tooth structure. Over the last two decades, tissue engineering has promoted from science fiction to science. Tissue enginee...

Background: The article aims to review osteogenic differentiation enhancement in human Dental Pulp Mesenchymal Stem Cells (hDPMSCs). Material and Methods: literature was carried out PUBMED with the keywords: (hDPMSCs) differentiation. Conclusions: Many research investigated impact of different compounds on hDPMSCs appliance by which these promote osteogenesis are a potential source for bone reg...

INTRODUCTION The loss of dental pulp may weaken teeth, rendering them susceptible to reinfection, fracture, and subsequent tooth loss. Therefore, regeneration of pulp is considered an ideal treatment to preserve teeth. The aim of this study was to explore the capacity of dental pulp stem cells (DPSCs) and platelet-rich plasma (PRP) to regenerate dental pulp in canine mature permanent teeth. M...

Current gold-standard strategies for bone regeneration do not achieve the optimal recovery of biomechanical properties. To bypass these limitations, tissue engineering techniques based on hybrid materials made up osteoprogenitor cells—such as mesenchymal stem cells (MSCs)—and bioactive ceramic scaffolds—such calcium phosphate-based (CaPs) bioceramics—seem promising. The biological properties MS...

Background. The treatment of pulp inflammation takes an important place among modern dentistry problems. Depulpated teeth in some cases become chronic source infection. They could also cause odontogenic infection the maxillofacial region. In this regard, it is to use conservative methods eliminate inflammatory process dental and preserve vitality tooth. Aim. aim study collect systematize inform...

BACKGROUND Dental pulp stem cells (DPSCs) play an important role in tissue regeneration. This study compares the growth kinetics and characterization of third molar and first premolar human DPSCs. MATERIAL AND METHODS Dental pulp tissues were isolated from human first premolar and third molar teeth and were digested by treating them with collagenase type I. Single-cell suspensions from each d...