نتایج جستجو برای: purine
تعداد نتایج: 10371 فیلتر نتایج به سال:
When cultures of Escherichia coli are partially inhibited by sulfonamides they accumulate a diazotizable and nonacetylable amine in the medium (Fox, 1942). The amine was isolated by Stetten and Fox (1945) and characterized by Shive et al. (1947) as 4-amino-5-imidazole carboxamide. The latter authors suggested that the amine was a precursor of purines as it only required the addition of a one ca...
Purine biosynthesis and metabolism, conserved in all living organisms, is essential for cellular energy homeostasis and nucleic acid synthesis. The de novo synthesis of purine precursors is under tight negative feedback regulation mediated by adenosine and guanine nucleotides. We describe a distinct early-onset neurodegenerative condition resulting from mutations in the adenosine monophosphate ...
Armitt & Woods (1970) and Lomax & Woods (1973) reported the isolation of a series of mutants of Saccharomyces cerevisiae that did not require purines for growth, but excreted substantial amounts of purines into the growth medium. Genetic studies have assigned these yeast strains to six unlinked genes (purl, pur2, pur3, pur4, pur.5, pzv6), of which one, pur6, had both recessive and dominant (PUR...
Purines are molecules essential for many cell processes, including RNA and DNA synthesis, regulation of enzyme activity, protein synthesis and function, energy metabolism and transfer, essential coenzyme function, and cell signaling. Purines are produced via the de novo purine biosynthesis pathway. Mutations in purine biosynthetic genes, for example phosphoribosylaminoimidazole carboxylase/phos...
Enzymes in the de novo purine biosynthesis pathway are recruited to form a dynamic metabolic complex referred to as the purinosome. Previous studies have demonstrated that purinosome assembly responds to purine levels in culture medium. Purine-depleted medium or 2-dimethylamino4,5,6,7-tetrabromo-1H-benzimidazole (DMAT) treatment stimulates the purinosome assembly in HeLa cells. Here, several me...
Controversy exists as to whether the purine nucleotide cycle is important in normal skeletal muscle function. Patients with disruption of the cycle from a deficiency of AMP deaminase exhibit variable degrees of muscle dysfunction. An animal model was used to examine the effect of inhibition of the purine nucleotide cycle on muscle function. When the compound 5-amino-4-imidazolecarboxamide ribos...
This study was designed to answer the question whether human lymphocytes and spleen cells were capable of de novo purine biosynthesis. Experiments were carried out in cell-free extracts prepared from human spleen, and from a cell line established from Burkitt lymphoma. Burkitt lymphoma cells and human spleen cells could synthesize the first and second intermediates of the purine biosynthetic pa...
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