Brønsted acid promoted nucleophilation of propargylic alcohols during the Meyer-Schuster rearrangement (M-S) has been introduced. A novel concept of reverse polarization of the M-S intermediate allenyl cation has been realized by employing a cis-enoate assisted strategy. This idea is well demonstrated by the metal free synthesis of complex, highly functionalized cyclic as well as acyclic α-aryl...

Diazocoupling reaction of curcumin with different diazonium salts of p-toluidine, 2-aminopyridine, and 4-aminoantipyrine in pyridine yielded the arylhydrazones 2a-c. Arylhydrazone of p-toluidine reacted with urea, thiourea, and guanidine nitrate to produce 5,6-dihydropyrimidines. Further reaction of 2a with 2,3-diaminopyrdine in sodium ethoxide solution yielded 1H-pyrido[2,3-b][1,4]diazepine de...

This work examines theoretically the problem of migration borane groups between nitrogen atoms pyrazolyl rings. We have studied as a model BH2 derivatives pyrazol-1-yl to determine effects substituents on pyrazole ring; also 1-(9-borabicyclo[3.3.1]nonan-9-yl)-1H-pyrazoles compare calculated barriers with experimental ones well steric effects, i.e. how buttressing effect increases rate. The inte...

Abstract The one‐bond nucleophilic reactivities of seven cyclic α‐diazo carbonyl compounds in dichloromethane were determined by analyzing the kinetics their reactions with benzhydrylium ions (one‐bond reference electrophiles) at 20 °C according to Mayr‐Patz equation. Though not calibrated for pericyclic reactions, identified nucleophilicities also reflect relative 1,3‐dipolar cycloadditions di...

This review summarizes the data on stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) related compounds obtained by multipulse multinuclear 1H, 13C, 15N NMR spectroscopy quantum chemistry. The stereochemistry is a challenging topic theoretical research, as correct interpretation their chemical behavior biological activity depends unde...

b a ckground: the present study was designed to investigate the insecticidal efficacy of four different classes of in-secticides: pyrethroids, organophosphates, phenyl-pyrazoles and neo-nicotenoids. one representative chemical from each class was selected to compare the toxicity: deltamethrin from pyrethroids, dichlorovinyl dimethyl phosphate (ddvp) from organophosphates, fipronil from phenyl-p...

           3-(2’-n-butylbenzofuran-3’-yl)-5-aryl-4, 5-dihydro-1H-pyrazoles (4a-4k) have been synthesized. The synthesized products have been assayed for their antimicrobial activity against Gram+ve,      Gram-ve bacteria and fungi. All the synthesized products were assigned with IR, 1HNMR, Mass Spectra, TLC, and elemental analysis. Some of the products showed moderate activi...

           3-(2’-n-butylbenzofuran-3’-yl)-5-aryl-4, 5-dihydro-1H-pyrazoles (4a-4k) have been synthesized. The synthesized products have been assayed for their antimicrobial activity against Gram+ve,      Gram-ve bacteria and fungi. All the synthesized products were assigned with IR, 1HNMR, Mass Spectra, TLC, and elemental analysis. Some of the products showed moderate activi...