نتایج جستجو برای: pyridinyl
تعداد نتایج: 490 فیلتر نتایج به سال:
Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models ...
Nicotine exposure results in health risks not only for smokers but also second- and third-hand smokers. Unraveling nicotine’s degradation mechanism the harmful chemicals that are produced under different conditions is vital to assess risks. We performed a theoretical study describe early chemistry of nicotine by investigating two important reactions can undergo: hydrogen abstraction hydroxyl ra...
The host-guest interaction between orthophosphate, pyrophosphate and triphosphate anions and three cyclen-based macrotricyclic ligands was investigated by potentiometric measurements and NMR spectroscopy. The ligands differ from one another by the nature of their spacers, which are 1,3-dimethylbenzene (TMC), 2,6-dimethylpyridine (TPyC) or a combination of the two (TMPyC). In aqueous solution, e...
10-Nornaltrexones (3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-benzofuro[3,2-e]isoquinolin-7(7aH)-one, 1) have been underexploited in the search for better opioid ligands, and their enantiomers have been unexplored. The synthesis of trans-isoquinolinone 2 (4-aH, 9-O-trans-9-methoxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-benzofuro[3,2-e]isoquinolin-7(7aH)-one) was achieved through...
Two new dinickel complexes with anthyridine-based ligands, 5-phenyl-2,8-bis(2-pyridinyl)-1,9,10-anthyridine () and 5-phenyl-2,8-bis(6'-bipyridinyl)-1,9,10-anthyridine (), are reported. Complexation of Ni(OAc)2 with and in trifluoroacetic acid provided the corresponding dinickel complexes [{Ni2()(H2O)6(CF3COO)2}(CF3COO)2] () and [Ni2()(CF3COO)4(H2O)] (), respectively. Both complexes were charact...
Imidacloprid [ 1-[(6-Chloro-3-Pyridinyl) methyl ]N-nitro -2Imidazolidinimine] is a newly introduced broad spectrum systemic insecticide in the Indian subcontinent by M/s. Bayer India Ltd.. This new chloronicotinyl compound is fairly soluble in water as compared to other non-polar insecticides (Kagabu 1997). It is effective against sucking insects, soil insects, termites and some species of chew...
Using N,N-dimethylacetalamide (DMAc) as the suspension media of polystyrene (PS) and poly[styrene-co-(4-vinyl-pyridin)] (PSVP) nanoparticles, insitu condensation polymerization of dianhydride and diamine was carried out and homogenous polyamic acid solution containing the nanoparticles were obtained. Novel PMDA-ODA nanocomposite membranes with various contents of nanoparticles were prepared by ...
One-electron oxidized guanine is an important reactive intermediate in the formation of oxidatively generated damage in DNA and a variety of methods have been utilized for the abstraction of a single electron from the guanine moiety. In this study, an alternative approach for the site specific, independent generation of the guanine radical, utilizing N-hydroxypyrid-2(1H)-one as a photolabile mo...
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