By ALFRED GELLHORN, M.D., AND LOGAN 0. JONES, M.D. E VIDENCE from animal experimentation indicates that pyridoxine, a cornponent of the vitamin B complex, is an essential factor for the maintenance and function of hematopoietic tissue. Severe anemia has been induced in dogs’ and swine2 on a pyridoxine deficient diet and the integrity of lymphoid tissue in rats has also been demonstrated to be d...

The absorption of pyridoxine from the intestine of the mouse was studied in whole animals. [3H]Pyridoxine was orally administered and the distribution of isotope between the six recognized forms of vitamin B6 was determined in portal and peripheral blood after the administration. When small doses (1.4 or 14 nmol) were administered, labeled pyridoxine could hardly be found in the portal blood as...

By HENRY FOY AND ATHENA KONDI p YRIDOXINE. Deficiency of pyridoxine (vitamin B11) has been shown to produce an anemia in dogs, rats, pigs, monkeys, chicks and ducks.1’#{176} Poikilocytosis in cattle has been successfully treated with pyridoxine.1#{176} Ramalingaswami and Sinclair1 I have shown that the hematologic abnormality in pyridoxine-deficient rats is a microcytosis, but it is not necessa...

background: migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. there are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. hence, this study aimed to assess the effects of pyridoxine  supplementation on severity, frequency and duration of migraine attacks as well as head...

A dose-response experiment with seven supplemental pyridoxine levels (0, 0.66, 1.32, 1.98, 2.64, 3.30, and 3.96 mg/kg) was conducted to investigate the effects of pyridoxine on growth performance and plasma aminotransferases and homocysteine of White Pekin ducks and to estimate pyridoxine requirement for these birds. A total of 336 one-day-old male White Pekin ducks were divided to 7 experiment...

Refractory status epilepticus describes continuing seizures despite adequate initial pharmacologic treatment. This situation is common in children, but few data are available to guide management. We review the literature related to the pharmacologic treatment and overall management of refractory status epilepticus, including midazolam, pentobarbital, phenobarbital, propofol, inhaled anesthetics...

three levels of lysine (90, 100 and 110% of ross requirement) and of pyridoxine (3, 6 and 9 mg kg-1) were used in a 3 × 3 factorial experiment to investigate the growth and blood antioxidant ability of broilers under high ambient temperature. none of the dietary supplements affected the weight gain during the starter and grower periods. although no significant differences were detected between ...

An epidemic illness characterized by head nodding associated with onchocerciasis has been described in eastern Africa since the early 1960s; we summarize published reports and recent studies. Onset of nodding occurs in previously healthy 5-15-year-old children and is often triggered by eating or cold temperatures and accompanied by cognitive impairment. Its incidence has increased in Uganda and...

Isolated rabbit iris--ciliary body preparations were found to accumulate 3H-pyridoxine by a mechanism that was time- and temperature-dependent, saturable in part, but not altered by omission of oxygen or specific ions. Tissue accumulation was only partially energy-dependent, and metabolic inhibitors had only small effects. Other B6 vitamers markedly blocked accumulation. Metabolism of 3H-pyrido...

When weanling rats were given 70% casein diet deficient in pyridoxine, they showed marked accumulation of liver lipid consisting mainly of triglyceride (TG) and cholesterol ester (CE). The serum concentrations of phospholipid (PL) and cholesterol (CH) in pyridoxine deficient rats were significantly lower than those in pair-fed controls, but their serum levels of TG and free fatty acid (FFA) wer...