The M-type potassium channel, of which its molecular basis is constituted by KCNQ2-5 homo- or heteromultimers, plays a key role in regulating neuronal excitability and is modulated by many G protein-coupled receptors. In this study, we demonstrate that histamine inhibits KCNQ2/Q3 currents in human embryonic kidney (HEK)293 cells via phosphatidylinositol 4,5-bisphosphate (PIP(2)) hydrolysis medi...

BACKGROUND The question of whether personality traits influence health has long been a focus for research and discussion. Therefore, this study was undertaken to examine possible associations between personality traits and mortality in women. METHODS A population-based sample of women aged 38, 46, 50 and 54 years at initial examination in 1968-69 was followed over the course of 40 years. At b...

A primary and a secondary neural network are applied to secondary structure and structural class prediction for a database of 681 non-homologous protein chains. A new method of decoding the outputs of the secondary structure prediction network is used to produce an estimate of the probability of finding each type of secondary structure at every position in the sequence. In addition to providing...

BACKGROUND There is debate as to whether the association between C-reactive protein (CRP) and insulin resistance is independent of body fatness, particularly central obesity. Therefore, the association among CRP, insulin resistance and obesity was analyzed in Chinese patients with type 2 diabetes. METHODS The study included 520 Chinese patients diagnosed with type 2 diabetes with CRP levels n...

We extend the open source Quake 3 Arena code base released by Id Software to include modification friendly code segments, art asset blueprints, external agent control and perception interfaces, game interaction logging, and a tool set that allows the creation of test beds for artificial agents. Our current modification work in the Urban Combat Testbed using the Q3 Mod Base is currently being us...

Background Substance abuse services treatment providers are challenged in making decisions regarding evidence-based assessment tools and processes, given the many options available in terms of length/coverage and administration options, including clinician versus self-administration. In Ontario, Canada, we have pilot-tested an assessment tool designed for clinician administration (the GAIN Q3-M...

The search theory approach to understanding unemployment flourished during the 1980s and 1990s. It has provided economists with a rich set of models for analyzing unemployment and labor market issues more generally. Unfortunately, while economists have found modern search theory to be an invaluable tool, the insights provided by this approach remain largely unfamiliar to noneconomists. This rev...

22 23 24 25 26 27 28 29 30 31 Q3 Article history: Received 21 February 2010 Received in revised form 13 January 2011 Accepted 13 January 2011 Available online xxxx

We previously reassigned the amber UAG stop triplet as a sense codon in Escherichia coli by expressing a UAG-decoding tRNA and knocking out the prfA gene, encoding release factor 1. UAG triplets were left at the ends of about 300 genes in the genome. In the present study, we showed that the detrimental effect of UAG reassignment could be alleviated by increasing the efficiency of UAG translatio...