BACKGROUND Quercetin, the predominant flavonoid, has been reported to lower the risk of several cancers. This flavonoid found in onion, grapes, green vegetables, etc. has been shown to possess potent antiproliferative effects against various malignant cells. This study was designed to investigate its effects on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) proteins se...

FOUR KNOWN FLAVONOIDS quercetin 3-O-β-D-rutinoside (Q3Rut), myricetin 3-O-β-D-galactopyranoside (M3Gal), quercetin 3-O-β-D-galactopyranoside (Q3Gal) and quercetin 3-O-β-D-glucopyranoside (Q3Glc), for the first time were isolated from aerial parts of Euphorbia microsciadia. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques....

A tannin, EA (1), and other nine non-tannins compounds, gallic acid (2), quercetin (3), myricetin (4), 3-O-methylellagic acid-4?-O-?-L-rhamnopyranoside (5), quercetin-3-O-?-D-galactopyranoside (6), kaempferol-3-O-?-D-glucoside (7), quercetin-3-O-?-D-glucuronide (8), quercetin-3-O-rutinoside (9), 3,3?,4-tri-O-methylellagic acid-4?-O-?-D-glucopyranosyl (10) were isolated from a valuable medicinal...

Cranberry is reported to have health benefits including prevention of urinary tract infections and other chronic diseases, due to the high content of polyphenols including flavonols and flavan-3-ols. The aim of this study was to determine the clearance of flavonol glycosides and flavan-3-ols and/or their metabolites in human urine. Ten healthy women volunteers ingested 240 ml cranberry juice co...

The molecularly imprinted polymer based on polypyrrole film with incorporated graphene oxide was fabricated and used for electrochemical determination of quercetin. The electrochemical behavior of quercetin on the modified electrode was studied in detail using differential pulse voltammetry. The oxidation peak current of quercetin in B-R buffer solution (pH = 3.5) at the modified electrode was ...

Phytochemical investigation of the leaves of Sutherlandia frutescens led to the isolation of four new 3-hydroxy-3-methylglutaroyl-containing flavonol glycosides, sutherlandins A-D ( 1- 4). Their structures were elucidated by chemical and spectroscopic methods as quercetin 3- O- beta- D-xylopyranosyl(1 --> 2)-[6- O-(3-hydroxy-3-methylglutaroyl)]- beta- D-glucopyranoside ( 1), quercetin 3- O- bet...

five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of rapistrum rugosum and their structures were assigned from 1h- and 13c-nmr spectra (dept) with 2d nmr as quercetin-3-o-α-l-rhamnopyranoside (1), quercetin-3-o-β-d-xyloside (2), quercetin, 3-o-α-l-arabinopyranoside,7-o-α-l-rhamnopyranoside (3), kaempferol 3-o-α-l-arabinopyranoside, 7-o-α-l-rham...

Flavonoids are a class of polyphenolic compounds widely distributed in the plant kingdom, which display a variety of biological activities, including chemoprevention and tumor growth inhibition. Our aim was to investigate the effects of several polyphenols on the growth and metastatic potential of B16-BL6 melanoma cells in vivo. Intraperitoneal administration of quercetin, apigenin, (-)-epigall...

Objective Indiscriminate use of synthetic pyrethroid insecticides, Cypermethrin (Cyp) and Deltamethrin (Del) have been reported to cause system toxicity in mammals including humans. The dietary antioxidants protects tissues and organs against insecticides/xenobiotic induced damage. In present study, we evaluated the effect of exposure of Cyp and Del and possible protective roles of curcumin and...

The relationship between glial lactate release and glial intracellular pH (pHi) regulation is studied using C6 glioma cells and rat astrocytes in vitro, and the lactate transport inhibitors quercetin and alpha-cyano-4-hydroxycinnamate (CHC). pHi is measured using 2',7'-bis(carboxyethyl)-5,6-carboxyfluorescein (BCECF). The results show that lactate release is mediated partly by a specific lactat...