Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200-250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before...

The purpose of the present study was to explore the utility of sandwich-cultured rat hepatocytes as an in vitro tool to examine drug interactions at the hepatic transport level. Rhodamine 123 was used as a model substrate for P-glycoprotein-mediated biliary excretion. Effects of various types of P-glycoprotein modulation on the biliary excretion index (BEI; a relative measure of the extent of b...

Gas hydrates presented as form of segregated bodies have been observed on shallow subsurface sediments. However, most gas hydrate physics models describe that hydrates occur in pore space in deep subsurface sediment. A new model considers gas hydrate as segregated bodies to derive elastic properties of hydrates bearing sediments and gas hydrate saturation. The predicted elastic properties based...

Introduction: rheumatoid arthritis characterized by joint inflammation and pain,affecting millions of peoples around the world. Traditional system medicine hadproven to be preventive treating physical mental illness. Objective: theobjective study is assess anti-arthritic potential plant Rosa alba L byconsidering CFA, formaldehyde turpentine oil induced arthritic model. Materialand Method: ethan...

Recent observations have evidenced traces of methane (CH4) heterogeneously distributed in the martian atmosphere. However, because the lifetime of CH4 in the atmosphere of Mars is estimated to be around 300–600 years on the basis of photochemistry, its release from a subsurface reservoir or an active primary source of methane have been invoked in the recent literature. Among the existing scenar...

Objective: Shiwei Qingwen decoction (SWQWD) is effective in preventing COVID-19. This study examined the active components of SWQWD and its potential targets for The used network pharmacology molecular docking technology to verify role through animal experiments explored mechanisms that enhance immunity alleviate mild COVID-19 symptoms. Methods: First, SWQWD- COVID-19-related were retrieved fro...

Quercetin is a flavonoid usually found in fruits and vegetables. Aside from its antioxidative effects, quercetin, like other flavonoids, has a various neuropharmacological actions. Quercetin-3-O-rhamnoside (Rham1), quercetin-3-O-rutinoside (Rutin), and quercetin- 3-(2(G)-rhamnosylrutinoside (Rham2) are mono-, di-, and tri-glycosylated forms of quercetin, respectively. In a previous study, we sh...

We present 1–5 lm IR reflectance spectra of CO2 clathrate hydrates acquired under temperature and pressure conditions representative of the icy moons’ surfaces. The IR reflectance spectrum of the CO2 clathrate hydrates is similar to the water ice IR reflectance spectrum except for two main absorption bands corresponding to the CO2 guest molecule at 2.71 and 4.28 lm (3693 and 2334 cm!1). The spe...

A Raman spectrometer extensively modified for deep ocean use was used to measure synthetic hydrates formed in an ocean environment. This was the first time hydrates formed in the ocean have been measured in situ using Raman spectroscopy. Gas hydrates were formed in situ in the Monterey Bay by pressurizing a Pyrex cell with various gas mixtures. Raman spectra were obtained for sI methane hydrate...