Sir, Angiotensin-converting enzyme (ACE) inhibitors are the most frequently prescribed antihypertensive drugs. Their effects on both hypertension and heart failure are highly beneficial. However, one has to be aware of the potential side effects, approximately 50% occurring in the skin. While angioedema is a well-known adverse cutaneous reaction to ACE inhibitors, other skin reactions are uncom...

Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells in vitro. Consistent with this, Ang II enhances neointimal proliferation in vivo after vascular injury, while angiotensin converting enzyme (ACE) inhibitors attenuate this process. Since tissue ACE plays a key role in the control of local Ang II production, we examined whether vascular injury resulted in an increase in vasc...