Desmin protofilaments and the proteolytically derived alpha-helical rod domain have been characterized by high-resolution gel permeation chromatography (GPC) using columns calibrated for the determination of viscosity radii. Additional characterization by chemical cross-linking and the determination of sedimentation values allowed the calculation of the molecular dimensions of the molecular spe...

T HE ewe is generally considered to be seasonally polyestrual in that she exhibits one or more diestrual cycles during a particular season of the year (Frank and Appelby, 1943). However, estrual activity may vary from the monestrual type exhibited by the wild sheep (Asdell, 1946) to the completely polyestrual type of some breeds in certain locations (Roberts, 1921; Kupfer, 1928; Quinlan and Mar...

computational mesh Discretize the continuous problem on the mesh Solve the nonlinear algebraic problem Update particle positions Update mesh node positions If mesh is distorted: Multi-Level Adaptive Solutions to Boundary-Value Problems. Achi Brandt, Mathematics of Computation, 31(138):333~ 390, April, 1977. Overture: An Object Oriented Framework for Solving Partial Differential Equations. David...

Native platelet factor-4 (PF4) is an asymmetrically associated, homo-tetrameric protein (70 residues/subunit) known for binding polysulphated glycosaminoglycans like heparin. PF4 N-terminal chimeric mutant M2 (PF4-M2), on the other hand, forms symmetric tetramers [Mayo, Roongta, Ilyina, Milius, Barker, Quinlan, La Rosa and Daly (1995) Biochemistry 34, 11399-11409] making NMR studies with this 3...

Leonard A. Breslow and David W. Aha Navy Center for Applied Research in Arti cial Intelligence Naval Research Laboratory Washington, DC 20375 fbreslow,[email protected] http://www.aic.nrl.navy.mil/ fbreslow,ahag 1 Problem and Contribution Induced decision trees are frequently used by researchers in the machine learning and statistics communities to solve classi cation tasks (Breiman et al. ...

The conditional independence assumption of naive Bayes essentially ignores attribute dependencies and is often violated. On the other hand, although a Bayesian network can represent arbitrary attribute dependencies, learning an optimal Bayesian network from data is intractable. The main reason is that learning the optimal structure of a Bayesian network is extremely time consuming. Thus, a Baye...

The major DNA-binding protein or infected cell protein 8 (ICP8) encoded by herpes simplex virus exhibits multiple interactions with the cell nucleus in that it interacts with the host cell nuclear matrix and viral DNA molecules as sequential stages in its maturational process (M. P. Quinlan, L. B. Chen, and D. M. Knipe (1984), Cell 36, 857-868). To define the portion(s) of ICP8 required for DNA...

RISE (Domingos 1995; in press) is a rule induction algorithm that proceeds by gradually generalizing rules, starting with one rule per example. This has several advantages compared to the more common strategy of gradually specializing initially null rules, and has been shown to lead to significant accuracy gains over algorithms like CGRULES and CN2 in a large number of application domains. Howe...

W e’ll begin with a prediction: years from now it will become obvious to observe that cross-cultural differences result substantially from regional differences in the prevalence of infectious diseases. Does that sound presumptuous? Perhaps even preposterous? Maybe. For many readers, our prediction may seem like a provocation that we’ve made up out of thin air. That’s not quite so. The scientifi...

To appear in W. Cohen & H. Hirsh (eds.), Machine Learning: Proceedings of the Eleventh International Conference. (New Brunswick NJ, July 1994.) Morgan Kaufmann, San Francisco CA. We discuss the implications of Holte’s recentlypublished article, which demonstrated that on the most commonly used data very simple classification rules are almost as accurate as decision trees produced by Quinlan’s C...