The interaction of molecular iodine with virus DNA nucleotide is studied by ab initio RHF/321G** method. Formation of the nucleoprotein complex of the HIV DNA, molecular iodine and the HIV-1 integrase co-factor is considered to cause the inhibition action of the integrase enzyme. Experimental data on the anti-HIV effect of the molecular iodine complex compounds and the results of calculations s...

BACKGROUND Radiocontrast agents are some of the most commonly used medications in the emergency department. However, both physicians and patients misunderstand the role that allergies play in reactions to radiocontrast media, especially with regards to shellfish and iodine. OBJECTIVES We sought to review the literature describing rates of contrast reactions and risk of contrast administration...

We report in this study the in vivo efficacy of nine 2-substituted quinolines on the Leishmania amazonensis cutaneous infection murine model and on the Leishmania infantum and Leishmania donovani visceral infection murine models. In the case of the L. amazonensis model, quinolines were administered orally at 25 mg/kg twice daily for 15 days. Quinolines 1, 2, 3, and 7 reduced by 80 to 90% the pa...

Palladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can be selectively obtained in moderate-to-good yields via intramolecular C-H alkenylation reactions,...

A novel and metal-free I2-mediated intramolecular C2 amidation of indoles under mild reaction conditions is developed. This methodology affords various indole fused tetracyclic compounds, such as benzo[4,5]imidazo[1,2-a]indoles by intramolecular C2 amidation of N-aryl substituted indoles. This C2 sulfonamidative cyclization also offers convenient access to indolo[2,3-b]indoles and dihydroindolo...

A novel multicomponent synthesis of ketene dithioacetal rhodanines has been reported by reactions of primary amine, carbon disulfide, ethyl chloroacetate, and alkyl halide in DMF. The catalytic effects of different bases have been investigated and potassium carbonate can efficiently catalyze the reaction in moderate to good yields at room temperature. 2013 Elsevier Ltd. All rights reserved. Mul...

a green and efficient one pot, three component protocol for synthesis of naphthopyranopyrimidines by cyclocondensation of β-naphthol, aldehyde, and 6-amino-1,3-dimethyluracil using l-proline as a beneficial catalyst with high catalytic activity under solvent-free conditions at 100 °c is described. in this study, several types of aromatic aldehyde, containing electron-withdrawing groups as well ...

The fundamental aspects of chemical reaction kinetics at near-critical conditions are discussed within the framework of transition state theory and the thermodynamics of critical phenomena for multicomponent systems. This discussion emphasizes the geometric analysis of Griffiths and Wheeler which describes the manner in which various thermodynamic properties behave on approaching mixture critic...

Colonies of Schizosaccharomyces pombe that contain ascospores (e.g., colonies of homothallic strains) turn black after treatment with iodine vapors. Heterothallic strains of S. pombe normally do not show this reaction. In experiments with the latter strains we found mutants which exhibit a positive iodine reaction though they do not contain ascospores. This phenotype is due to mutations in a ne...